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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > Cellular physiology

The Cancer Code - A Revolutionary New Understanding of a Medical Mystery (Paperback): Dr. Jason Fung The Cancer Code - A Revolutionary New Understanding of a Medical Mystery (Paperback)
Dr. Jason Fung
R368 Discovery Miles 3 680 Ships in 12 - 17 working days

Our understanding of cancer is slowly undergoing a revolution, allowing for the development of more effective treatments. For the first time ever, the death rate from cancer is showing a steady decline ... but the 'War on Cancer' has hardly been won. In The Cancer Code, Dr Jason Fung offers a revolutionary new understanding of this invasive, often fatal disease - what it is, how it manifests and why it is so challenging to treat. In this rousing narrative, Dr Fung identifies the medical community's many missteps in cancer research - in particular, its focus on genetics, or what he terms the 'seed' of cancer, at the expense of examining the 'soil,' or the conditions under which cancer flourishes. Dr Fung - whose ground-breaking work in the treatment of obesity and diabetes has won him international acclaim - suggests that the primary disease pathway of cancer is caused by the dysregulation of insulin. In fact, obesity and type 2 diabetes significantly increase an individual's risk of cancer. In this accessible read, Dr Fung provides a new paradigm for dealing with cancer, with recommendations for what we can do to create a hostile soil for this dangerous seed. One such strategy is intermittent fasting, which reduces blood glucose, lowering insulin levels. Another, eliminating intake of insulin-stimulating foods, such as sugar and refined carbohydrates. For hundreds of years, cancer has been portrayed as a foreign invader we've been powerless to stop. By reshaping our view of cancer as an internal uprising of our own healthy cells, we can begin to take back control. The seed of cancer may exist in all of us, but the power to change the soil is in our hands.

Encyclopedia of Cell Biology (Hardcover, 2nd edition): Ralph A. Bradshaw, Philip D. Stahl, Gerald W. Hart Encyclopedia of Cell Biology (Hardcover, 2nd edition)
Ralph A. Bradshaw, Philip D. Stahl, Gerald W. Hart
R63,206 Discovery Miles 632 060 Ships in 12 - 17 working days

Encyclopedia of Cell Biology, Second Edition, a Six Volume Set, has established itself as a fundamental reference work, providing broad coverage of the field in four main sections (Molecular, Organizational, Functional, Translational and Pathological Aspects of Cell Biology). This second edition revisits and expands each section, with entries on topics not covered in the first edition, including Crispr. The whole work is updated, providing greater coverage of specialized cell function and translational applications, and putting greater emphasis on these topics in graduate/medical teaching. New overview chapters and subsections provide a simplified cell biology text that can be used by instructors. The new version includes a standard template for each chapter, making the content easier to navigate, as well as inserts and graphics which provide summaries of key points in each chapter.

Endothelial Progenitor Cells - A New Real Hope? (Hardcover, 1st ed. 2017): Carmela Rita Balistreri Endothelial Progenitor Cells - A New Real Hope? (Hardcover, 1st ed. 2017)
Carmela Rita Balistreri
R2,886 Discovery Miles 28 860 Ships in 10 - 15 working days

This book explores the role of endothelial progenitor cells (EPCs) in the context of regenerative medicine (RegMed). In particular, it reveals the value of RegMed as a new TM branch intended to improve the health and quality of life, by restoring, maintaining or enhancing tissue and functions of organs. The book is divided into three chapters, the first of which describes the relevance of translational medicine (TM) as a new research approach to counteract the imposing challengeof age-related diseases. Of the diverse RegMed approaches, particular attention is paid to stem/progenitor cell-based therapies, their benefits and shortcomings, as well as to the description of types of stem and progenitor cells considered for regenerative cell therapies, such as EPCs as emerging candidates for RegMed applications. In turn, the second chapter outlines the clinical relevance of EPCs as both potential predictors, diagnostic and prognostic biomarkers of age-related diseases and therapeutic agents,discussing their advantages, disadvantages, and conflicting data. Chapter three proposes a potential roadmap for revising the findings and creating a clearer picture of valid data, which can provide support for various important aspects, i.e.isolating and characterizing EPCs by establishing standardized criteria for EPC research, identifying appropriate sub-populations for cell therapy, timing, dosing, priming of cells,and defining delivery modes for different applications. The book concludes with an overview of innovative strategies that could improve the efficacy of cell therapy at all levels, including cell priming, bio-nanotechnology, and tissue engineering.

The Male Role in Pregnancy Loss and Embryo Implantation Failure (Hardcover, 1st ed. 2015): Richard Bronson The Male Role in Pregnancy Loss and Embryo Implantation Failure (Hardcover, 1st ed. 2015)
Richard Bronson
R4,723 R3,678 Discovery Miles 36 780 Save R1,045 (22%) Ships in 12 - 17 working days

Novel topics compiled in this one-of-a-kind volume provide tantalizing hints for clinical application through future translational research. Only recently have we come to ask what role the male might play in pregnancy loss and embryo implantation failure, beyond contributing an abnormal set of paternal chromosomes at fertilization. This volume explores the recent evidence that these conditions might also be related to the transmission of previously unrecognized chromosomal micro-deletions and duplications, or via the epigenetic dysregulation of early embryonic gene function by spermatozoal microRNAs or alterations in sperm DNA methylation patterning, or by DNA damage secondary to either reactive oxygen species or environmental toxicants. In addition, the composition of seminal plasma has been found to be highly complex, containing many factors that play important roles in altering the uterine environment and the female immune system permissive of embryo implantation and trophectoderm outgrowth leading to successful pregnancy. Coverage includes an examination of both spermatozoa and seminal fluid component factors.

BRS Physiology (Paperback, Eighth, International Edition): Linda S Costanzo BRS Physiology (Paperback, Eighth, International Edition)
Linda S Costanzo
R1,127 Discovery Miles 11 270 Ships in 12 - 17 working days

The leading physiology review on the market, BRS Physiology, 8th Edition, delivers a concise, highly efficient review of all essential physiology concepts students encounter in the first and second year of medical school, as well as more than 350 clinical vignette-style, multiple-choice questions to help them prepare for course exams and practice for the USMLE Step 1. This bestselling title in the Board Review Series is preferred by students for its comprehensive yet efficient approach to exam prep and trusted by instructors for author Linda S. Costanzo's masterful approach, communicating complex physiology concepts in an accessible manner. Extensively updated and incorporating abundant illustrations, flow charts, tables, and a comprehensive practice exam, this 8th Edition equips today's students with the unparalleled preparation and confidence to excel on exams and beyond. Study efficiently with a concise outline format that makes essential information easy to review at a glance. Prepare for course and board exams with topical chapter questions and a 100-question Comprehensive Exam, accompanied by complete answers, rationales, and cross-references for efficient remediation. More than 260 multiple-choice questions in chapter exams test students' understanding of chapter content; detailed explanations provide an additional learning tool. Build long-term retention with more than 120 full-color illustrations and charts that clarify complex information, as well as 50 detailed tables. Reference essential information conveniently with appendices on Key Physiology Topics for the USMLE Step 1, Key Physiology Equations for the USMLE Step I, and Normal Blood Values. Create connections between physiology knowledge and clinical medicine with new Clinical Correlation boxes.

Essentials of Stem Cell Biology (Hardcover, 3rd edition): Robert Lanza, Anthony Atala Essentials of Stem Cell Biology (Hardcover, 3rd edition)
Robert Lanza, Anthony Atala
R4,200 Discovery Miles 42 000 Ships in 12 - 17 working days

First developed as an accessible abridgement of the successful "Handbook of Stem Cells," "Essentials of Stem Cell Biology" serves the needs of the evolving population of scientists, researchers, practitioners, and students embracing the latest advances in stem cells. Representing the combined effort of 7 editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, and methods to theapplication of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.
Contributions by Nobel Laureates and leading international investigatorsIncludes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthroughEdited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debatePresented in full color with a glossary, highlighted terms, and bibliographic entries replacing references"

Oxidative Eustress in Exercise Physiology (Hardcover): James N. Cobley, Gareth W. Davison Oxidative Eustress in Exercise Physiology (Hardcover)
James N. Cobley, Gareth W. Davison
R3,186 Discovery Miles 31 860 Ships in 12 - 17 working days

Describes essential redox biology reactions and concepts in exercise physiology. Defines and critiques how to assess and manipulate key redox parameters in an in vivo human exercise context. Summarizes underlying mechanisms. Provides examples of translationally important research relating to many disease states. Includes an international team of leading experts

Cellular Therapy for Neurological Injury (Paperback): Jr Charles S Cox Cellular Therapy for Neurological Injury (Paperback)
Jr Charles S Cox
R1,424 Discovery Miles 14 240 Ships in 12 - 17 working days

Cellular Therapy for Neurological Injury discusses the current status of cellular therapy for neurological disorders. The primary areas of focus include traumatic brain injury, stroke (ischemic and hemorrhagic), and spinal cord injury. The book explores cell therapy approaches to these and other conditions, while discussing current advances and a literature review in the context of a field that is moving rapidly. The book presents a translational focus, addressing barriers and opportunities to moving forward. The mechanisms of injury are explored, as well as how these mechanisms influence the type of cell therapy used, the route of delivery, and dosing regimen. Written by leaders in the field, this is an invaluable resource for clinicians and researchers alike.

Cancer Stem Cells - Philosophy and Therapies (Hardcover): Lucie Laplane Cancer Stem Cells - Philosophy and Therapies (Hardcover)
Lucie Laplane
R989 R937 Discovery Miles 9 370 Save R52 (5%) Ships in 12 - 17 working days

An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than treat cancer by aggressively trying to eliminate all cancerous cells-with harmful side effects for patients-CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells-the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs-their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell's relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers.

Essentials of Apoptosis - A Guide for Basic and Clinical Research (Hardcover, 2nd ed. 2009): Xiao-Ming Yin, Zheng Dong Essentials of Apoptosis - A Guide for Basic and Clinical Research (Hardcover, 2nd ed. 2009)
Xiao-Ming Yin, Zheng Dong
R5,778 Discovery Miles 57 780 Ships in 10 - 15 working days

This is the second edition of the comprehensive, concise summary of apoptosis research. It covers the major concepts, molecular architecture, the biochemical pathways, and pathophysiological significance of apoptosis. This book provides a guideline of standard biochemical and cell biologic approaches to apoptosis bench work with an emphasis on translational clinical applications for immune disorders, cancer research, ischemia, and neuronal degeneration. Since the original publication in 2003, the apoptosis field has expanded rapidly chapters not only need to be revised and expanded, but there is a need for all new chapters covering exciting advances in bioinformatics, systems biology, oxidative stress, etc."

Biomaterials for Stem Cell Therapy - State of Art and Vision for the Future (Hardcover): Loredana De Bartolo, Augustinus Bader Biomaterials for Stem Cell Therapy - State of Art and Vision for the Future (Hardcover)
Loredana De Bartolo, Augustinus Bader
R7,204 Discovery Miles 72 040 Ships in 12 - 17 working days

Focused on stem cell applications, this book bridges the fields of biomaterials, offering new insights into constructing and regenerating tissues and organs. Its unique feature is linking diseases of the human body to current thinking on how to deal with them in the context of current concepts and technologies by means of an in-depth focus on biomaterials. The book assembles recent advances and covers a range of topics related to stem cell biology, biomaterials and technological approaches such as bioreactors written by top researchers in the field. Stem cells of both embryonic and adult origin are discussed with applications ranging, but not limited to, nerve regeneration, liver, pancreas, skin, trachea, cartilage and bone repair and cardiovascular therapy. Developments in the field reflecting the design and construction of the human body and its principal anatomy are discussed from a materials point of view. The book will be a valuable tool for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells. It will also be a source of reference for students in biotechnology, biomedical engineering, biology, biochemistry, materials sciences, pharmaceuticals, and veterinary and human medicine.

Stem Cells and Bone Tissue (Hardcover): Rajkumar Rajendram, Victor R. Preedy, Vinood Patel Stem Cells and Bone Tissue (Hardcover)
Rajkumar Rajendram, Victor R. Preedy, Vinood Patel
R5,118 Discovery Miles 51 180 Ships in 12 - 17 working days

Stem cells potentially offer a novel therapeutic platform to treat bone disease. They also help the scientist understand the molecular and cellular aetiology of bone disorders. Gaining knowledge on the nature and application of stem cell sciences is a prerequisite for understanding their potential in treating or preventing bone disorders. Stem Cells and Bone Tissue is designed to address these areas in three sections: Introductory Text and Sources of Stem Cells for Skeletal Tissue Cellular and Molecular Aspects Conditions, Applications, Treatments and Repairs Coverage includes general aspects of stems cells, sources of stems cells, isolation and purification, applications in regeneration, nanoscale topography, myostatin (GDF-8) signalling, c-Jun, Lnk, cell-derived Factor 1/CXCR4, chromatin remodelling, osteoporosis, osteoarthritis, hypophosphatasia, osteopetrosis, osteogenesis, and many other areas of merit too numerous to mention.

Astrocytes - Wiring the Brain (Hardcover): Eliana Scemes, David C. Spray Astrocytes - Wiring the Brain (Hardcover)
Eliana Scemes, David C. Spray
R5,103 Discovery Miles 51 030 Ships in 12 - 17 working days

Astrocytes play diverse roles in central nervous system (CNS) function and dysfunction, and the connections that the astrocyte makes with other cells of the brain are essential for a variety of important neural tasks. Bringing together contributions from international experts at the top of their field, Astrocytes: Wiring the Brain emphasizes cellular connections and surveys the most current findings on astrocyte activity. The first section of the book identifies major astrocyte biomarkers and describes how they define the different connectivity domains. Next, the book examines the role of these connections. It explains how their function can be manipulated under physiological conditions and how dysfunction of the connectivity leads to aberrant brain performance. The final section explores the alterations of glia that have been observed in specific diseases of the brain. These include epilepsy, autoimmune encephalitis, Alzheimer's disease, autism, and major depression. The book identifies key mechanisms responsible for these alterations. An important and emerging field, astrocytes and their functions are critical to neuroscientists and neurologists, both in academia and in industry, particularly in the search for and development of new drugs to combat a variety of diseases affecting the CNS. As research continues to grow in this area, this volume will spur heightened advances and understanding into the effects of these neural cells on a range of pathologies.

Cellular Therapy for Neurological Injury (Hardcover): Jr Charles S Cox Cellular Therapy for Neurological Injury (Hardcover)
Jr Charles S Cox
R5,247 Discovery Miles 52 470 Ships in 12 - 17 working days

Cellular Therapy for Neurological Injury discusses the current status of cellular therapy for neurological disorders. The primary areas of focus include traumatic brain injury, stroke (ischemic and hemorrhagic), and spinal cord injury. The book explores cell therapy approaches to these and other conditions, while discussing current advances and a literature review in the context of a field that is moving rapidly. The book presents a translational focus, addressing barriers and opportunities to moving forward. The mechanisms of injury are explored, as well as how these mechanisms influence the type of cell therapy used, the route of delivery, and dosing regimen. Written by leaders in the field, this is an invaluable resource for clinicians and researchers alike.

Extracellular Vesicles in Health and Disease (Hardcover): Paul Harrison, Chris Gardiner, Ian L. Sargent Extracellular Vesicles in Health and Disease (Hardcover)
Paul Harrison, Chris Gardiner, Ian L. Sargent
R4,669 Discovery Miles 46 690 Ships in 12 - 17 working days

Interest in the role of extracellular vesicles (microvesicles and exosomes) is expanding rapidly. It is now apparent that far from being merely cellular debris, these vesicles play a key role in cell-to-cell communication and signaling. Moreover, they are significantly elevated in a number of diseases. This raises the question of their direct role in pathogenesis as well as their possible use as biomarkers.

This book stems from the first international meeting on "Microvesicles and Nanovesicles in Health and Disease" held at Magdalen College, Oxford, in 2010. The purpose of the meeting was to bring together, for the first time, a range of experts from around the world to discuss the latest advances in this field. Key to the study of these vesicles is the availability of methodologies for their measurement in biological fluids. A major section of the meeting focused on a range of exciting new technologies which have been developed for this purpose. The presentations at this meeting form the basis of this book, which will appeal to basic scientists, clinicians, and those developing technology for the measurement of extracellular vesicles.

Protein Formulation and Delivery (Hardcover, 2nd edition): Eugene J. McNally, Eugene McNally, Jayne E. Hastedt Protein Formulation and Delivery (Hardcover, 2nd edition)
Eugene J. McNally, Eugene McNally, Jayne E. Hastedt
R5,112 Discovery Miles 51 120 Ships in 12 - 17 working days

This title is intended to assist pharmaceutical scientists in the development of stable protein formulations during the early stages of the product development process, providing a comprehensive review of mechanisms and causes of protein instability in formulation development, coverage of accelerated stability testing methods and relevant analytical methods, and an overview of the drug substance manufacturing process. Preformulation and the development of traditional solutions and lyophilized formulations frequently used for intravenous delivery and non-traditional formulations are also addressed. Because many developments in the field have emerged since the publication of the First Edition, this Second Edition addresses important new patient-friendly developments in the field, such as formulation for implantable devices, needle-free formulation and delivery approaches, and oral delivery of proteins.

Methods in Molecular Biophysics - Structure, Dynamics, Function for Biology and Medicine (Hardcover, 2nd Revised edition):... Methods in Molecular Biophysics - Structure, Dynamics, Function for Biology and Medicine (Hardcover, 2nd Revised edition)
Nathan R. Zaccai, Igor N. Serdyuk, Joseph Zaccai
R1,725 Discovery Miles 17 250 Ships in 9 - 15 working days

Current techniques for studying biological macromolecules and their interactions are based on the application of physical methods, ranging from classical thermodynamics to more recently developed techniques for the detection and manipulation of single molecules. Reflecting the advances made in biophysics research over the past decade, and now including a new section on medical imaging, this new edition describes the physical methods used in modern biology. All key techniques are covered, including mass spectrometry, hydrodynamics, microscopy and imaging, diffraction and spectroscopy, electron microscopy, molecular dynamics simulations and nuclear magnetic resonance. Each method is explained in detail using examples of real-world applications. Short asides are provided throughout to ensure that explanations are accessible to life scientists, physicists and those with medical backgrounds. The book remains an unparalleled and comprehensive resource for graduate students of biophysics and medical physics in science and medical schools, as well as for research scientists looking for an introduction to techniques from across this interdisciplinary field.

Encyclopedia of Cell Biology (Hardcover, Annotated edition): Ralph A. Bradshaw, Philip D. Stahl Encyclopedia of Cell Biology (Hardcover, Annotated edition)
Ralph A. Bradshaw, Philip D. Stahl
R40,855 Discovery Miles 408 550 Ships in 12 - 17 working days

The Encyclopedia of Cell Biology, Four Volume Set offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences.

Apoptosis in Health and Disease (Hardcover): Robert R. Ruffolo Jr, Frank Walsh Apoptosis in Health and Disease (Hardcover)
Robert R. Ruffolo Jr, Frank Walsh
R5,093 Discovery Miles 50 930 Ships in 12 - 17 working days

The impact of Apoptosis, or programmed cell death, is thought to play a crucial role in the development and progression of disease. Whilst Apoptosis remains extensively studied in the context of immunology, the focus of research has greatly expanded to investigate the key role it is now believed to play in hematopoiesis, angiogenesis, inflammation and organ remodelling. It is hoped that, with an increase in our understanding of the mechanisms controlling apoptosis, there will come the development of a new class of drugs which can pharmacologically manipulate apoptosis and thus provide a means to treat important diseases which currently pose problems to our society.
Containing papers presented at the Eleventh SmithKline Beecham Pharmaceuticals United States Research Symposium and with contributions from leading researchers, Apoptosis in Health and Disease offers a comprehensive review of important developments and research in the field.

Chromogranins: from Cell Biology to Physiology and Biomedicine (Hardcover, 1st ed. 2017): Tommaso Angelone, Maria Carmela... Chromogranins: from Cell Biology to Physiology and Biomedicine (Hardcover, 1st ed. 2017)
Tommaso Angelone, Maria Carmela Cerra, Bruno Tota
R4,734 R3,663 Discovery Miles 36 630 Save R1,071 (23%) Ships in 12 - 17 working days

The volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell biology, physiology and biomedicine. The different chapters highlight novel activities of these proteins, including their role in granule biogenesis, hormone co-storage, stimulus-processing-secretion coupling, autonomic sympathetic/parasympathetic balance, immune and cardiocirculatory function, and the response to stress. Biomedical aspects are also illustrated with focus on the prognostic and diagnostic significance of Chromogranin in the presence of tumors, cardiovascular diseases and inflammatory conditions. The volume is of interest for laboratory and clinical scientists, PhD and Post-doc students that will be inspired to go deep inside the molecular, biochemical, physiological, pharmacological and clinical aspects of these fascinating multifaceted proteins.

Biochemistry and Cell Biology of Ageing: Part I Biomedical Science (Hardcover, 1st ed. 2018): J.Robin Harris, Viktor I.... Biochemistry and Cell Biology of Ageing: Part I Biomedical Science (Hardcover, 1st ed. 2018)
J.Robin Harris, Viktor I. Korolchuk
R7,264 Discovery Miles 72 640 Ships in 10 - 15 working days

This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.

Stem Cells and Bone Tissue (Paperback): Rajkumar Rajendram, Victor R. Preedy, Vinood Patel Stem Cells and Bone Tissue (Paperback)
Rajkumar Rajendram, Victor R. Preedy, Vinood Patel
R1,880 Discovery Miles 18 800 Ships in 12 - 17 working days

Stem cells potentially offer a novel therapeutic platform to treat bone disease. They also help the scientist understand the molecular and cellular aetiology of bone disorders. Gaining knowledge on the nature and application of stem cell sciences is a prerequisite for understanding their potential in treating or preventing bone disorders. Stem Cells and Bone Tissue is designed to address these areas in three sections: Introductory Text and Sources of Stem Cells for Skeletal Tissue Cellular and Molecular Aspects Conditions, Applications, Treatments and Repairs Coverage includes general aspects of stems cells, sources of stems cells, isolation and purification, applications in regeneration, nanoscale topography, myostatin (GDF-8) signalling, c-Jun, Lnk, cell-derived Factor 1/CXCR4, chromatin remodelling, osteoporosis, osteoarthritis, hypophosphatasia, osteopetrosis, osteogenesis, and many other areas of merit too numerous to mention.

Stem Cell Transplantation (Hardcover, 2012): Carlos Lopez-Larrea, Antonio Lopez Vazquez, Beatriz Suarez Alvarez Stem Cell Transplantation (Hardcover, 2012)
Carlos Lopez-Larrea, Antonio Lopez Vazquez, Beatriz Suarez Alvarez
R5,698 Discovery Miles 56 980 Ships in 10 - 15 working days

Organ transplantation has been the most important therapeutic advance in the last third of the 20th century. Its development has revolutionized medicine, as demonstrated by the fact that a large number of researchers in this field have been awarded Nobel Prizes. In the beginning of this century, we are witnessing with great expectations the emergence of a new field of medicine related to the arrival of a new player on the scene: "stem cells" and their potential use in regenerative medicine. This volume aims to cover important aspects of the various facets of organ transplantation and regenerative medicine, with leading specialists in these fields setting out their vision. We try to rigorously explain current and novel scientific research in these fields-areas which arouse great interest from society in general, due to their potential use in modern medicine for the treatment of a great number of diseases.

Biochemistry and Cell Biology of Ageing: Part II Clinical Science (Hardcover, 1st ed. 2019): J.Robin Harris, Viktor I. Korolchuk Biochemistry and Cell Biology of Ageing: Part II Clinical Science (Hardcover, 1st ed. 2019)
J.Robin Harris, Viktor I. Korolchuk
R6,510 Discovery Miles 65 100 Ships in 10 - 15 working days

This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.

Memory T Cells (Hardcover, Edition.): Maurizio Zanetti, Stephen P. Schoenberger Memory T Cells (Hardcover, Edition.)
Maurizio Zanetti, Stephen P. Schoenberger
R6,378 Discovery Miles 63 780 Ships in 10 - 15 working days

Immunological memory has fascinated microbiologists and immunologists for decades as one of the new frontiers to conquer to better understand the response to pathogens, cancer and vaccination. Over the past decade, attention has turned to the intrinsic properties of the memory T cells themselves, as it has become clear that the eradication of both infected cells and tumors requires T cells. This book is an attempt to capture the wave of discoveries associated with these recent studies. Its chapters represent a wide collection of topics related to memory T cells by laboratories that have invested their skills and knowledge to understand the biology and the principles upon which memory T cells are generated, maintained and expanded upon re-encounter with antigen. Ultimately, these studies are all aimed at a better understanding of the function of memory T cells in protection against disease.

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