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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > Cellular physiology
Current techniques for studying biological macromolecules and their interactions are based on the application of physical methods, ranging from classical thermodynamics to more recently developed techniques for the detection and manipulation of single molecules. Reflecting the advances made in biophysics research over the past decade, and now including a new section on medical imaging, this new edition describes the physical methods used in modern biology. All key techniques are covered, including mass spectrometry, hydrodynamics, microscopy and imaging, diffraction and spectroscopy, electron microscopy, molecular dynamics simulations and nuclear magnetic resonance. Each method is explained in detail using examples of real-world applications. Short asides are provided throughout to ensure that explanations are accessible to life scientists, physicists and those with medical backgrounds. The book remains an unparalleled and comprehensive resource for graduate students of biophysics and medical physics in science and medical schools, as well as for research scientists looking for an introduction to techniques from across this interdisciplinary field.
First published in 1943, "Vitamins and Hormones" is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on the pancreatic beta cell. Key features: Expertise of the contributorsCoverage of a vast array of subjectsIn depth current information at the molecular to the clinical levelsThree-dimensional structures in colorElaborate signaling pathways "
This book is a must-have for anyone interested in obesity or the
physiology of white or brown adipose tissues. It contains
state-of-the-art methods from researchers that are world leaders in
this field. Detailed lab protocols range from methods to visualize
adipocytes and adipose tissues in humans and experimental models,
to convert stem cells into white and brown adipocytes in vitro, to
evaluate aspects of adipocyte metabolism, to inducibly knock out
genes in adipose tissues, and to evaluate transcriptional control
of adipogenesis on a global scale. 1) The study of adipose tissue goes hand in hand with our global effort to understand and reverse the epidemic of obesity and associated medical complications. 2) Contributors include leading researchers who have made tremendous contributions to our ability to investigate white and brown adipose tissues. 3) The wide variety of experimental approaches detailed within this volume: including the evaluation of adipose tissue biology at the molecular, biochemical, cellular, tissue, and organismal levels.
This new volume of "Methods in Enzymology" continues the legacy
of this premier serial with quality chapters authored by leaders in
the field. This is the third of three volumes on hydrogen peroxide
and cell signaling, and includes chapters on such topics as the
biological chemistry of hydrogen peroxide, reactive oxygen species
in the activation of MAP kinases, and investigating the role of
reactive oxygen species in regulating autophagy.
This new volume of "Methods in Enzymology" continues the legacy
of this premier serial with quality chapters authored by leaders in
the field. This is the second of three volumes on hydrogen peroxide
and cell signaling, and includes chapters on such topics as the
cellular steady-state of H2O2, evaluating peroxiredoxin sensitivity
towards inactivation by peroxide substrates, and peroxiredoxins as
preferential targets in H2O2-induced signaling.
Written and edited by leaders in the field, " Eosinophils in
Health and Disease" provides immunology researchers and students
with a comprehensive overview of current thought and cutting-edge
eosinophil research, providing chapters on basic science,
disease-specific issues, therapeutics, models for study and areas
of emerging importance. Despite an explosion of discovery in this
area over the last decade, this is the onlyup-to-date resource on
eosinophils and eosinophilia exists. This full-color volumeprovides
an essential collection of world class information that is a
must-have for any immunologist s workbench or bookshelf.
In this thematic volume of "Progress in Molecular Biology and
Translational Science, "researchers reflect on recent developments
and research surrounding G protein-coupled receptors. The chapters
cover a large breadth of research, including GPCR role in stem cell
function and pharmacology. Authors explore in-depth research
techniques and applications of GPCR usage, covering theory,
laboratory approaches, and unique qualities that make GPCRs a
crucial tool in microbiological and cancer research. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field
This new volume of "Methods in Enzymology" continues the legacy of
this premier serial by containing quality chapters authored by
leaders in the field. This volume coversG protein
coupledreceptorsandincludes chapterson such topics as G
protein-coupled receptor trafficking motifs, structure-based
virtual screening, and automation-friendly high throughput assays
for identification of pharmacoperone drugs.
This new volume of "Methods in Enzymology" continues the legacy
of this premier serial by containing quality chapters authored by
leaders in the field. This volume covers G protein coupled
receptors and includes chapters on such topics as post-translation
modification of GPCR in relationship to biased agonism,
structure-based virtual screening, and GPCR oligomerization in the
brain.
Obesity is an epidemic with enormous health, economic and social
burdens. Current drugs for obesity treatment are far from ideal in
terms of efficacy and side effects. Reviews in this volume of
Progress in Molecular Biology and Translational Science summarize
current status in studies of a number of G protein-coupled
receptors that were shown to be promising targets for obesity
treatments. Some of these receptors also cause monogenic obesity in
humans. Chapters are written by leading experts.
This special volume of Progress in Molecular Biology and
Translational Science focuses on the genetics of stem cells. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field
"Cellular Physiology of Nerve and Muscle" offers a state of the art introduction to the basic physical, electrical, and chemical principles central to the function of nerve and muscle cells. The text begins with an overview of the origin of electrical membrane potential, then clearly illustrates the cellular physiology of nerve cells and muscle cells. Throughout, this new edition simplifies difficult concepts with accessible models and straightforward descriptions of experimental results. The fourth edition of Cellular Physiology of Nerve and Muscle features new material including: - An all-new introduction to electrical signaling in the nervous
system
This volume explores some of the most exciting recent advances in
basic research on cellular RNA interference mechanisms and how this
knowledge is leading to advances in the various fields.
Notch signaling is an evolutionarily conserved pathway in
multicellular organisms that regulates cell-fate determination
during development and in stem cells. This volume, which is part of
the Current Topics in Developmental Biology series, covers topics
such as Notch signaling in cardiac development and disease and
Notch in stem cells. International authors provide researchers with
an overview and synthesis of the latest research findings and
contemporary thought in the area.
This volume, along with its companion (volume 475), presents
methods and protocols dealing with thiol oxidation-reduction
reactions and their implications as they relate tocell signaling.
This firstinstallment of Cadenas and Packer's two-volume treatment
specifically deals with glutathionylation and dethiolation, and
peroxide removal by peroxiredoxins/thioredoxins and glutathione
peroxidases. The critically acclaimed laboratory standard for40
years, "Methods in Enzymology" is one of the most highly respected
publications in the field of biochemistry. Since 1955, each volume
has been eagerly awaited, frequently consulted, and praised by
researchers and reviewers alike.Over 450volumes have been published
to date, and much of the material is relevant even today--truly an
essential publication for researchers in all fields of life
sciences.
This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.
Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular characteristics of cell-to-cell communication via gap junctions. Key aspects of molecular structure, formation, gating, conductance, and permeability of vertebrate and invertebrate gap junction channels are highlighted. In addition, a number of chapters focus on recent discoveries that implicate connexin mutations and alterations of gap junctional communication in the pathogenesis of several diseases, including the X-linked Charcot-Marie-Tooth demyelinating disease, some forms of inherited sensorineural deafness, malignant transformation, cardiac malformations and arrhythmia, eye lens cataract, and Chagas disease.
A study of mast cells and basophils, designed for the use of immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
Vast numbers of different prokaryotic microorganisms shape the biosphere, with diverse metabolic capabilities. Determination of genome sequences for a wide range of bacteria and archaea now requires an in-depth knowledge of prokaryotic metabolic function to give biochemical, physiological and ecological meaning to the genomic information. This new edition describes up-to-date knowledge of the key metabolic processes that occur under different conditions, and the cellular processes that determine prokaryotic roles in the environment, biotechnology and human health. Essential for students of microbiology, applied microbiology, biotechnology, genomics and systems biology, this advanced textbook covers prokaryotic structure, composition, nutrient transport, biosynthesis and growth. Newly characterised metabolic pathways are included, as well as the latest understanding of metabolic regulation and stress responses. Additionally, the link between energetics, growth and survival is discussed as well as the maintenance of genetic integrity by the bacterial immune system.
The endothelium, the cell layer that forms the inner lining of blood vessels, is a spatially distributed system that extends to all reaches of the human body. Today, clinical and basic research demonstrates that the endothelium plays a crucial role in mediating homeostasis and is involved in virtually every disease, either as a primary determinant of pathophysiology or as a victim of collateral damage. Indeed, the endothelium has remarkable, though largely untapped, diagnostic and therapeutic potential. This volume endeavors to bridge the bench-to-bedside gap in endothelial biomedicine, with the goal of advancing research and development and improving human health. The book is the first to systematically integrate knowledge about the endothelium from different organ-specific disciplines, including neurology, pulmonary, cardiology, gastroenterology, rheumatology, infectious disease, hematology-oncology, nephrology, and dermatology. Moreover, it is unique in its interdisciplinary approach, drawing on expertise from such diverse fields as evolutionary biology, comparative biology, molecular and cell biology, mathematical modeling and complexity theory, translational research, and clinical medicine.
Immunological memory has fascinated microbiologists and immunologists for decades as one of the new frontiers to conquer to better understand the response to pathogens, cancer and vaccination. Over the past decade, attention has turned to the intrinsic properties of the memory T cells themselves, as it has become clear that the eradication of both infected cells and tumors requires T cells. This book is an attempt to capture the wave of discoveries associated with these recent studies. Its chapters represent a wide collection of topics related to memory T cells by laboratories that have invested their skills and knowledge to understand the biology and the principles upon which memory T cells are generated, maintained and expanded upon re-encounter with antigen. Ultimately, these studies are all aimed at a better understanding of the function of memory T cells in protection against disease.
Enzymology at the Membrane Interface, the latest volume in the Methods in Enzymology series, covers a subset of enzymes that work in the environment of the biological cell membrane. This field, called interfacial enzymology, involves a special series of experimental approaches for the isolation and study of these enzymes.
Enzymology at the Membrane Interface: Intramembrane Proteases, Volume 584, the latest release in the Methods in Enzymology series, covers a subset of enzymes that work in the environment of the biological cell membrane. This field, called interfacial enzymology, involves a special series of experimental approaches for the isolation and study of these enzymes.
What every neuroscientist should know about the mathematical modeling of excitable cells. Combining empirical physiology and nonlinear dynamics, this text provides an introduction to the simulation and modeling of dynamic phenomena in cell biology and neuroscience. It introduces mathematical modeling techniques alongside cellular electrophysiology. Topics include membrane transport and diffusion, the biophysics of excitable membranes, the gating of voltage and ligand-gated ion channels, intracellular calcium signalling, and electrical bursting in neurons and other excitable cell types. It introduces mathematical modeling techniques such as ordinary differential equations, phase plane, and bifurcation analysis of single-compartment neuron models. With analytical and computational problem sets, this book is suitable for life sciences majors, in biology to neuroscience, with one year of calculus, as well as graduate students looking for a primer on membrane excitability and calcium signalling.
A Laboratory Guide to the Tight Junction offers broad coverage of the unique methods required to investigate its characteristics. The methods are described in detail, including its biochemical and biophysical principles, step-by-step process, data analysis, troubleshooting, and optimization. The coverage includes various cell, tissue, and animal models. Chapter 1 provides the foundations of cell biology of tight junction. Chapter 2 covers the Biochemical approaches for paracellular channels and is followed by chapter 3 providing the Biophysical approaches. Chapter 4 describes and discusses Histological approaches for tissue fixation and preparation. Chapter 5 discusses Light microscopy, while chapter 6 presents Electron microscopic approaches. Chapter 7 covers Transgenic manipulation in cell cultures, including DNA and siRNA, Mutagenesis, and viral infection. Chapter 8 covers transgenic manipulation in mice, including: Knockout, Knockin, siRNA knockdown, GFP/LacZ reporter, and overexpression. The final chapter discusses the future developments of new approaches for tight junction research. Researchers and advanced students in bioscience working on topics of cell junction, ion channel and membrane protein will benefit from the described methods. Clinicians and pathologists interested in tissue barrier diseases will also benefit from the biochemical and biophysical characterization of tight junctions in organ systems, and their connection to human diseases. |
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