Natural Killer (NK) cells are large granular lymphocytes of the
innate immune system. They are widespread throughout the body,
being present in both lymphoid organs and non-lymphoid peripheral
tissues. NK cells are involved in direct innate immune reactions
against viruses, bacteria, parasites and other triggers of
pathology, such as malignant transformation, all of which cause
stress in affected cells. Importantly, NK cells also link the
innate and adaptive immune responses, contributing to the
initiation of adaptive immune responses and executing adaptive
responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such
responses are mediated through two major effector functions, the
direct cytolysis of target cells and the production of cytokines
and chemokines. The authors focus here on the nature of recognition
events by NK cells and address how these events are integrated to
trigger these distinct and graded effector functions.
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