The aquaporin field has matured at an exceptionally fast pace
and we are at the verge to develop serious strategies to
therapeutically modulate aquaporin function directly or via
regulatory networks. Key prerequisites are available today: i. a
considerable (and growing) number of aquaporin crystal structures
for the rational design of inhibitory molecules, ii. elaborate
molecular dynamics simulation techniques for theoretical analyses
of selectivity mechanisms and docking experiments, iii.
comprehensive data on aquaporin immunohistochemistry, iv. aquaporin
knockout animals for physiological studies, and v. assay systems
for compound library screenings. The structure of this volume on
aquaporins follows the points laid out above and thus covers the
developments from basic research to potential pharmacological use.
Situated between pharmacology textbooks and recent scientific
papers this book provides a timely overview for readers from the
fundamental as well as the applied disciplines.
General
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