Autophagy Networks in Inflammation (Hardcover, 1st ed. 2016)

Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Progress in Inflammation Research
Release date:	August 2016
First published:	2016
Editors:	Maria Chiara Maiuri • Daniel A deStefano
Dimensions:	235 x 155 x 31mm (L x W x T)
Format:	Hardcover
Pages:	403
Edition:	1st ed. 2016
ISBN-13:	978-3-319-30077-1
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > Cellular physiology Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General Promotions
LSN:	3-319-30077-6
Barcode:	9783319300771

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