This book deals with many recent advances made in uncovering the
molecular and cellular basis of phagocytosis of apoptotic and
necrotic dying cells as well as with the methods used for studying
their clearance. There are important practical and clinical reasons
for attempting to understand the molecular mechanisms of
phagocytosis of dying cells, because inadequate clearance of dying
cells may contribute to the development of autoimmune diseases
(e.g. systemic lupus erythematosus), as well as atherosclerosis and
chronic lung diseases (e.g. chronic obstructive pulmonary disease,
asthma and cystic fibrosis). Furthermore, in this book we examine
the possibility of using apoptotic cells in the prevention and
treatment of graft rejection and in the rational design of
immunotherapy and vaccines for cancer treatment. The role of
environmental factors in phagocytosis of dying cells is also
addressed.
This comprehensive volume integrates the most innovative and
current findings from several related disciplines of scientific
research, including pathology, immunology, genetics, and cellular
and molecular biology. It is divided into two sections: "Molecular
mechanisms of phagocytosis of dying cells" and "Impairment of
phagocytosis of dying cells and its role in the development of
diseases." No other recent books devoted to this subject are
available.
All of the contributors are experts working at the forefront of
scientific discovery, and the reviews they present systematically
examine the most exciting and innovative aspects of their
particular areas of expertise. Both researchers and physicians will
find this volume of major benefit because it covers the
immunological and molecular biological aspects of phagocytosis of
dying cells as well as its clinical relevance.
General
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