Response of Different Species to Total Body Irradiation (Paperback, Softcover reprint of the original 1st ed. 1984)

J.J. Broerse, Radiobiological Institute TNO, Rijswijk, The Netherlands, and T .J. MacVittie, Armed Forces Radiobiology Research Institute, Bethesda, MD, USA. During the past decade, relatively few new studies have been initiated on the response of different species to high-dose, total-body irradia- tion. For information on the LDSO/30d (the dose which produces 50 percent lethality within 30 days), one is generally referred to the older literature (e. g., Bond, Fliedner and Archambeau, 1965). Compari- son of experimental data reveals considerable variations in LDSD values even after total-body irradiation with conventional X rays, ranging from 4 to 6 Gy in the monkey, 7.1 to 9 Gy in the rat and from 6.4 to 9 Gy in the mouse (see also Hall, 1978). Part of the discrepancy in the LDso values can possibly be attributed to inadequacies in the dosimetry procedures and exposure arrangements employed. As far as clinical experience is concerned, there is now an appreciable amount of information available about the effect of total- body irradiation as a conditioning treatment for bone marrow transplan- tation in patients suffering from leukaemia or aplastic anaemia. The results from different centres, including the incidence of complications such as radiation pneumonitis, are considerably different. This can part I y be connected with the application of different radiation sched- ules: large single dose versus fractionated or protracted irradiation.

General

Imprint:	Springer
Country of origin:	Netherlands
Series:	Series in Radiology, 10
Release date:	October 2011
First published:	1984
Editors:	J.J. Broerse • T.J. Macvittie
Dimensions:	235 x 155 x 13mm (L x W x T)
Format:	Paperback
Pages:	244
Edition:	Softcover reprint of the original 1st ed. 1984
ISBN-13:	978-9400960503
Categories:	Books > Medicine > Other branches of medicine > Medical imaging > Radiology Promotions
LSN:	9400960506
Barcode:	9789400960503

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