Progress in Clinical and Biological Research, Volume 397
ENDOTOXIN AND SEPSIS
Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy
Proceedings of the Fourth Conference of the International Endotoxin
Society Held in Nagoya, Japan, October 23-27, 1996
Jack Levin, Matthew Pollack, Takashi Yokochi, and Masayasu Nakano,
Editors
Recent breakthroughs in our understanding of the molecular biology
of the human immune response have lead to important advances in the
recognition and treatment of sepsis. Endotoxin and Sepsis:
Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy
compiles the latest basic and clinical research on many aspects of
sepsis, including sepsis/SIRS. It provides researchers and
clinicians with an up-to-date overview of the critical data and
concepts in this rapidly progressing field of inquiry.
Featuring contributions by researchers and clinicians from around
the world, this book presents papers covering a broad spectrum of
specialized topics in the bacteriology, biochemistry, molecular and
cellular interactions, pathophysiology, and pharmacodynamics of
sepsis/SIRS. It also presents information on in vivo detection and
potential new therapies that target sepsis and its cellular
effects. Specific topics covered in Endotoxin and Sepsis: Molecular
Mechanisms of Pathogenesis, Host Resistance, and Therapy include:
* Enzymes essential to the biosynthesis of Lipid A and their
importance in the design of a new generation of antibiotics
* Recent breakthroughs in the understanding of the role of CD-14 in
cellular resistance to infection and its therapeutic implications
* The role of Interleukin 6 in endotoxin-induced inflammatory
response
* The molecular mechanisms responsible for endotoxin tolerance
* Unique chemical and biological features of LPS, and natural and
synthetic LPS control mechanisms.
Endotoxin and Sepsis: Molecular Mechanisms of Pathogenesis, Host
Resistance, and Therapy is must reading for laboratory and clinical
microbiologists, immunologists, and other investigators studying
bacterial endotoxins, and specialists in internal medicine. It will
also be of interest to biotechnology and pharmaceutical researchers
involved with the development of new drugs to combat sepsis.
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