Practitioners of obstetrics, maternal-fetal medicine and
consultants in other branches of medicine who help provide
excellent care to pregnant patients with hypertensive complications
of pregnancy will welcome this compendium about HELLP Syndrome.
Drawing upon the expertise of 37 contributors from 15 institutions
and four countries, this book summarises the state of the science
and practice for patients with HELLP syndrome. On a global basis,
what we call HELLP syndrome accounts for hundreds to thousands of
maternal deaths and is responsible for many more thousands of
patients that suffer "near miss" mortality, which we more properly
term "severe maternal morbidity". Our understanding of this
pregnancy scourge -- the basic science or bench aspects -- is still
relatively inadequate to fully comprehend the pathogenesis and the
pathophysiology of this condition as it relates to its close
relative, the syndromic disorder of preeclampsia. Although a
corticosteroid-based management scheme has shown great promise in
practice and has a strong physiologic basis, there remains a need
for a high quality, large-scale (1000+ patients) constructed,
prospective placebo-controlled clinical trial involving a
heterogeneous patient population to fully and objectively evaluate
this approach to practice. The need and the urgency are great given
the risk of HELLP to mothers and babies.
General
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