The introduction of prostaglandins into clinical practice has been
one of the most important advances in obstetrics and gynaecology in
recent years. During the last decade obstetricians have become
familiar with these drugs for inducing labour and for terminating
second-trimester pregnancy. Within the last year their use has been
extended, in association with antiprogestin, to first-trimester
termi nation. Although the effectiveness of prostaglandins in these
pharma cological roles is clear, their full potential has still to
be explored, and much remains to be learned about their physiology.
Prostaglandins playa central role in the initiation of labour.
Further clarification of this role could lead to improvements in
preventing or treating preterm labour, which still remains the most
important cause of perinatal mortality in this country.
Prostaglandins are also inti mately involved in the mechanism of
menstruation. More detailed understanding of this role should lead
to more effective treatments for menorrhagia and dysmenorrhoea.
These substances also playa part in the mechanism of implantation,
and further research in this area may lead to more effective
therapy for infertility.
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