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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
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Peptide Research Protocols - Endothelin (Hardcover, 2002 ed.)
Loot Price: R2,939
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Peptide Research Protocols - Endothelin (Hardcover, 2002 ed.)
Series: Methods in Molecular Biology, 206
Expected to ship within 10 - 15 working days
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The endothelins are a remarkable family of signaling peptides:
molecular biology predicted the existence of their receptors and
synthetic enzymes prior to both the identification of the encoded
proteins and the synthesis of antagonists and inhibitors for use as
pharmacological tools. Although considerable advances have been
made, culminating in the design of endothelin antagonists with the-
peutic potential in cardiovascular disease, much remains to be
discovered. Tantalizingly, new research frontiers are emerging. To
support further progress, Peptide Research Protocols: Endothelin
encompasses experimental protocols that interrogate all facets of
an endogenous mammalian peptide s- tem, from peptide and receptor
expression through synthetic pathway to peptide function and
potential role in human disease. Chapters describe the use of
molecular techniques to quantify the expression of mRNA for both
endothelin receptors and the endothelin-converting enzymes.
Peptides, precursors, receptors, and synthetic enzymes may be
localized and quantified in plasma, culture supernatants, tissue
homogenates, and tissue s- tions using antibodies, while additional
information on receptor characterization may be obtained using
radioligand binding techniques. Several protocols cover in vitro
assays that determine the function of the endothelin peptides in
isolated preparations, that characterize new endothelin receptor
ligands, or provide inf- mation on the tissue-specific processing
of endothelin precursor peptides.
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