The present project concerns the development of once-daily floating
matrix tablets, which after oral administration show prolonged
gastric residence and extended release of drug. The asymmetric
screening matrix, a D-optimal design, was used for finding out the
significant formulation factors. Tablets were obtained by wet
granulation of drug with HPMC K100M and various excipients,
followed by compression and were evaluated for buoyancy lag time, Q
6h, Q 24h and floating duration, during screening study. The
graphical analysis of coefficients was done to find out significant
factors. The response surface modeling (RSM) was performed with
significant factors obtained from screening study.The D-optimal
design was used for RSM and various prediction plots and contour
plots were used for RSM. The desirability function was used to
combine all the responses for optimization. The Nelder-Mead simplex
method was applied for optimization of formulation. The optimized
formulation was evaluated for diff. parameters and compared with
marketed formulation.Various model dependent and model independent
drug release parameters of optimized formulation were comparable to
that of marketed formulatio
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