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Polymyxin Antibiotics: From Laboratory Bench to Bedside (Hardcover, 1st ed. 2019)
Loot Price: R5,349
Discovery Miles 53 490
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Polymyxin Antibiotics: From Laboratory Bench to Bedside (Hardcover, 1st ed. 2019)
Series: Advances in Experimental Medicine and Biology, 1145
Expected to ship within 10 - 15 working days
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This volume is the first-ever complete treatise on polymyxins and
presents the most comprehensive and up-to-date reviews of all major
research and clinical topics from chemistry, microbiology,
pharmacology, clinical use, to drug discovery. All chapters were
written by internationally leading researchers and clinicians in
the field. It is our wish that readers discover the importance of
polymyxin structure in relation to the mechanisms of activity,
resistance and toxicity. We emphasized that reliable analytic
methods for polymyxins are critical when investigating their
pharmacokinetics (PK) and pharmacodynamics (PD). The complicated
dose definitions and different pharmacopoeial standards have
already compromised the safe use of polymyxins in patients.
Therefore, informed by the latest pharmacological information,
scientifically-based dosing recommendations have been proposed for
intravenous polymyxins. Considering the PK/PD limitations and
potential development of resistance, polymyxin combinations are
encouraged; however, the current literature has not shown definite
microbiological benefits, possibly because most clinical studies to
date overlooked key PK/PD principles. Nephrotoxicity is the major
dose-limiting factor and it is imperative to elucidate the
mechanisms and develop novel approaches to minimize
polymyxin-associated toxicities. In addition, the anti-endotoxin
effect of polymyxins supports their clinical use to treat
Gram-negative sepsis. Fortunately, the discovery of new-generation
polymyxins with wider therapeutic windows has benefited from the
latest achievements in polymyxin research. This book provides
extensive pharmacological information on polymyxins to infectious
diseases clinicians, pharmacists, clinical microbiologists,
antimicrobial pharmacologists, and pharmaceutical scientists, and
is an essential read for those who aim to develop novel polymyxins
and improve their clinical use as a last-line defense against
Gram-negative 'superbugs'.
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