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Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical) > Bacteriology

Metabolic Engineering for Bioactive Compounds - Strategies and Processes (Hardcover, 1st ed. 2017): Vipin Chandra Kalia, Adesh... Metabolic Engineering for Bioactive Compounds - Strategies and Processes (Hardcover, 1st ed. 2017)
Vipin Chandra Kalia, Adesh Kumar Saini
R5,843 Discovery Miles 58 430 Ships in 7 - 11 working days

This book comprehensively discusses the latest research in the area of metabolic engineering. Metabolic engineering solutions for bioactive compounds are now being derived by means of heterologous gene expression, in a wide range of organisms. The book provides an overview of the model systems being employed for metabolic manipulation to yield bioactive molecules, such as single-cell proteins, antibody generation, metabolites, proteases, chaperones, therapeutic proteins, nanomaterials, polymeric conjugates, dendrimers and nanoassemblies, Escherichia coli, Agrobacterium, Saccharomyces cerevisiae and cell lines, etc. In addition, it shares insights into the scope of these methods in the areas of prevention, diagnosis and treatment of diseases, e.g. immunotherapy for curing various diseases like cancer, allergies, autoimmune diseases, etc.

Probiotics in Agroecosystem (Hardcover, 1st ed. 2017): Vivek Kumar, Manoj Kumar, Shivesh Sharma, Ramprasad Probiotics in Agroecosystem (Hardcover, 1st ed. 2017)
Vivek Kumar, Manoj Kumar, Shivesh Sharma, Ramprasad
R6,790 Discovery Miles 67 900 Ships in 7 - 11 working days

This book focuses on food security in sustainable agriculture and nutrient management. The study of plant probiotic microbes' synergism using existing techniques has greatly improved our grasp of the structure and functioning of the plant microbiome. However, the function of plant probiotic microbes and their relation to plants' health in the context of food security, soil nutrient management, human and plant health are largely unexplored. Compared to human probiotics, diverse types and millions of microbiota inhabit plants, forming multifaceted and complicated ecological societies that stimulate plant growth and health through their combined metabolic activities. From the perspective of sustainable cropping systems, observing plant probiotics can provide insights on how to stimulate and maintain plant productivity, along with host stress tolerance and recycling of soil nutrients. This book combines reviews and original research articles to highlight the latest advances in plant probiotics, their specificity, diversity, function, as well as plant microbiome management to improve plant growth and productivity, nutrient management and human health.

Modern Topics in the Phototrophic Prokaryotes - Environmental and Applied Aspects (Hardcover, 1st ed. 2017): Patrick C.... Modern Topics in the Phototrophic Prokaryotes - Environmental and Applied Aspects (Hardcover, 1st ed. 2017)
Patrick C. Hallenbeck
R6,182 Discovery Miles 61 820 Ships in 7 - 11 working days

This book offers authoritative contributions by world experts actively working on different aspects of phototrophic prokaryotes. Providing up-to-date information in this rapidly advancing field, it covers the range of topics that are currently the focus of research with this group of organisms. As essentially single-celled organisms, phototrophic prokaryotes process many environmental signals and use this information to optimize their metabolism, growth rate, DNA replication and cell division. Phototrophic prokaryotes are collectively of great interest for a number of different fundamental and applied perspectives and have long served as models for understanding such basic fundamental biological processes as photosynthesis and respiration. On an ecological/environmental level they are extremely important, being the most abundant photosynthetic organisms on earth and responsible for the majority of the primary productivity in the oceans. They also hold great promise as biotechnological catalysts, being able to couple solar energy conversion through photosynthesis and carbon fixation to the production of biofuels, commodity chemicals and neutraceuticals. The book is recommended to advanced students and scientists dealing with life sciences, especially in genetics, microbiology and molecular biology.

The Prokaryotes - Other Major Lineages of Bacteria and The Archaea (Hardcover, 4th ed. 2014): Eugene Rosenberg The Prokaryotes - Other Major Lineages of Bacteria and The Archaea (Hardcover, 4th ed. 2014)
Eugene Rosenberg; Edited by Edward F. DeLong, Stephen Lory, Erko Stackebrandt, Fabiano Thompson
R17,985 Discovery Miles 179 850 Ships in 7 - 11 working days

The Prokaryotes is a comprehensive, multi-authored, peer reviewed reference work on Bacteria and Achaea. This fourth edition of The Prokaryotes is organized to cover all taxonomic diversity, using the family level to delineate chapters.

Different from other resources, this new Springer product includes not only taxonomy, but also prokaryotic biology and technology of taxa in a broad context. Technological aspects highlight the usefulness of prokaryotes in processes and products, including biocontrol agents and as genetics tools.

The content of the expanded fourth edition is divided into two parts: Part 1 contains review chapters dealing with the most important general concepts in molecular, applied and general prokaryote biology; Part 2 describes the known properties of specific taxonomic groups.

Two completely new sections have been added to Part 1: bacterial communities and human bacteriology. The bacterial communities section reflects the growing realization that studies on pure cultures of bacteria have led to an incomplete picture of the microbial world for two fundamental reasons: the vast majority of bacteria in soil, water and associated with biological tissues are currently not culturable, and that an understanding of microbial ecology requires knowledge on how different bacterial species interact with each other in their natural environment. The new section on human microbiology deals with bacteria associated with healthy humans and bacterial pathogenesis. Each of the major human diseases caused by bacteria is reviewed, from identifying the pathogens by classical clinical and non-culturing techniques to the biochemical mechanisms of the disease process.

The 4th edition of The Prokaryotes is the most complete resource on the biology of prokaryotes.

The following volumes are published consecutively within the 4th Edition:

Prokaryotic Biology and Symbiotic Associations

Prokaryotic Communities and Ecophysiology

Prokaryotic Physiology and Biochemistry

Applied Bacteriology and Biotechnology

Human Microbiology

Actinobacteria

Firmicutes

Alphaproteobacteria and Betaproteobacteria

Gammaproteobacteria

Deltaproteobacteria and Epsilonproteobacteria

Other Major Lineages of Bacteria and the Archaea"

Bergey's Manual of Systematic Bacteriology - Volume 4: The Bacteroidetes, Spirochaetes, Tenericutes (Mollicutes),... Bergey's Manual of Systematic Bacteriology - Volume 4: The Bacteroidetes, Spirochaetes, Tenericutes (Mollicutes), Acidobacteria, Fibrobacteres, Fusobacteria, Dictyoglomi, Gemmatimonadetes, Lentisphaerae, Verrucomicrobia, Chlamydiae, and Planctomycetes (Hardcover, 2nd ed. 2010)
Aidan Parte; Edited by Noel R. Krieg, Wolfgang Ludwig, William B Whitman, Brian P. Hedlund, …
R7,095 R5,956 Discovery Miles 59 560 Save R1,139 (16%) Ships in 10 - 15 working days

Includes a revised taxonomic outline for the phyla Bacteroidetes, Planctomycetes, Chlamydiae, Spirochetes, Fibrobacters, Fusobacteria, Acidobacteria, Verrucomicrobia, Dictyoglomi, and Gemmatomonadetes based upon the SILVA project as well as a description of more than 153 genera in 29 families. Includes many medically important taxa.

Listeria Monocytogenes - Methods and Protocols (Hardcover, 2nd ed. 2021): Edward M. Fox, Helene Bierne, Beatrix Stessl Listeria Monocytogenes - Methods and Protocols (Hardcover, 2nd ed. 2021)
Edward M. Fox, Helene Bierne, Beatrix Stessl
R4,225 Discovery Miles 42 250 Ships in 7 - 11 working days

This updated book explores a wide repertoire of tools and approaches that have been created, modified, and applied to the study of L. monocytogenes, forming the basis of our understanding of the bacterium today. Many of these key experimental techniques are gathered together herein. The volume presents aspects such as clinical disease and host-pathogen interactions, as well as the study of biofilms which present a significant challenge for control of the organism in the food processing environment. The topics covered in this edition also include sampling in order to isolate Listeria, methods for their identification and characterization, methods for gene manipulation, and methods for control of the organism. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Listeria monocytogenes: Methods and Protocols, Second Edition aims to contribute toward the harmonization of methods used to study this important bacterium, and to be of particular interest to Listeria research both in relation to food association and control as well as clinical microbiology.

Probiotics and Plant Health (Hardcover, 1st ed. 2017): Vivek Kumar, Manoj Kumar, Shivesh Sharma, Ramprasad Probiotics and Plant Health (Hardcover, 1st ed. 2017)
Vivek Kumar, Manoj Kumar, Shivesh Sharma, Ramprasad
R6,006 Discovery Miles 60 060 Ships in 7 - 11 working days

This book primarily focuses on microbial colonization, its role in plant growth and nutrient cycling, mycorrhizae, and providing an overview of phytospheric microorganisms in sustainable crop systems. Despite the advances made in the study of plant-microbe synergism, the relation between microbes and plant health in the context of food security, soil nutrient management, human and plant health is still largely unexplored. Addressing that gap, the book presents reviews and original research articles that highlight the latest discoveries in plant probiotics, their specificity, diversity and function. Additional sections addressing nutrient management, human health, and plant microbiome management to improve plant productivity round out the coverage.

Prokaryotic Metabolism and Physiology (Paperback, 2nd Revised edition): Byung Hong Kim, Geoffrey Michael Gadd Prokaryotic Metabolism and Physiology (Paperback, 2nd Revised edition)
Byung Hong Kim, Geoffrey Michael Gadd
R1,318 Discovery Miles 13 180 Ships in 10 - 15 working days

Vast numbers of different prokaryotic microorganisms shape the biosphere, with diverse metabolic capabilities. Determination of genome sequences for a wide range of bacteria and archaea now requires an in-depth knowledge of prokaryotic metabolic function to give biochemical, physiological and ecological meaning to the genomic information. This new edition describes up-to-date knowledge of the key metabolic processes that occur under different conditions, and the cellular processes that determine prokaryotic roles in the environment, biotechnology and human health. Essential for students of microbiology, applied microbiology, biotechnology, genomics and systems biology, this advanced textbook covers prokaryotic structure, composition, nutrient transport, biosynthesis and growth. Newly characterised metabolic pathways are included, as well as the latest understanding of metabolic regulation and stress responses. Additionally, the link between energetics, growth and survival is discussed as well as the maintenance of genetic integrity by the bacterial immune system.

Yersinia pestis: Retrospective and Perspective (Hardcover, 1st ed. 2016): Ruifu Yang, Andrey Anisimov Yersinia pestis: Retrospective and Perspective (Hardcover, 1st ed. 2016)
Ruifu Yang, Andrey Anisimov
R7,129 Discovery Miles 71 290 Ships in 7 - 11 working days

This book addresses nearly every aspect of Y. pestis, approaching it from a new perspective. Topics covered include the history, epidemiology, physiology, ecology, genome, evolution, pathogenesis, host-pathogen interaction, big-data-driven research, vaccines, clinical aspects and future research trends. For centuries, scientists have sought to determine where Y. pestis, the most well-known bacterium and one that has caused a number of high-mortality epidemics throughout human history, comes from, what it is and how it causes the disease. This book works to answer these questions with the help of cutting-edge research results. It not only describes the history of plagues, but also stresses plagues' effects on human civilization and explores the interaction of Y. pestis with hosts, vectors and the environment to reveal the evolution and pathogenesis. The book offers a valuable guide for researchers and graduate students studying Y. pestis, and will also benefit researchers from other fields, such as infectious diseases, other pathogens and system biology, sharing key insights into bacterial pathogen studies.

Pseudomonas: Molecular and Applied Biology (Hardcover, 1st ed. 2016): Rachhpal S. Kahlon Pseudomonas: Molecular and Applied Biology (Hardcover, 1st ed. 2016)
Rachhpal S. Kahlon
R5,363 Discovery Miles 53 630 Ships in 7 - 11 working days

This book provides a concise and comprehensive overview of the basic biology, genomics, biotechnological applications and role of Pseudomonas in agriculture, environment and industry. The Pseudomonas genus occupies a key position in medicine, the environment, agriculture and commercial biotechnology by virtue of its genetic diversity, metabolic adaptability and versatility and the broad array of ecological niches that it inhabits. Pseudomonas aeruginosa, an opportunistic pathogen, is known for its multiple drug resistance and is associated with cystic fibrosis and wound infections particularly in patients with burn injuries. Pseudomonas syringae is a plant pathogen and is responsible for major crop losses in horticultural, vegetable and field crops. Another species, P. fluorescens is known for promoting plant growth through the production of certain hormones and the biocontrol of soil-borne fungal diseases and insects. The ability to adapt to diverse and challenging environments and degrade recalcitrant compounds means that the genus is widely exploited for bioremediation, while their genetic diversity coupled with broad catalytic potential makes them valuable in biotransformation, synthesis of high-value chiral compounds for biosynthesis and production of biopolymers and bio-surfactants widely used in medicine, agriculture and industry. The book serves as a ready reference and text book for graduate students, young field microbiologists and research scientists in academia, research institutes and industry.

Helicobacter pylori Research - From Bench to Bedside (Hardcover, 1st ed. 2016): Steffen Backert, Yoshio Yamaoka Helicobacter pylori Research - From Bench to Bedside (Hardcover, 1st ed. 2016)
Steffen Backert, Yoshio Yamaoka
R5,395 Discovery Miles 53 950 Ships in 7 - 11 working days

This book provides the current updated knowledge on all essential aspects in the rapidly evolving area of Helicobacter pylori research. H. pylori is a class I carcinogen and one of the most common infections in the world. While most people colonized by H. pylori will remain asymptomatic, up to 20 % of them may develop serious gastroduodenal disease such as peptic ulcers or gastric cancer. H. pylori is the only known bacterium linked to the development of cancer and consequently is an important focus of research. Outstanding international experts from diverse scientific disciplines contribute here to give detailed insights into the current understanding concerning the physiology and role of this pathogen. Both basic science and clinical research with actual practical consequences are taken into account. The chapters target microbiology, epidemiology, genetics, biochemistry, interactions with the immune system, signal transduction, pathogenic mechanisms in the gastroduodenal mucosa, gastric disease development, and therapy including antibiotics or probiotics treatment as well as vaccination strategies. This book is an important reference not only for clinicians but also microbiologists. It provides in a single volume an up-to-date summary of our current knowledge of this microbe and the multiple ways in which it impacts upon public health in all parts of the world.

Detection & Decontamination of Bacillus Anthracis Spores in Soil (Paperback): Violet Imani Detection & Decontamination of Bacillus Anthracis Spores in Soil (Paperback)
Violet Imani
R1,475 Discovery Miles 14 750 Ships in 10 - 15 working days

The U.S. Environmental Protection Agency (EPA) Office of Research and Development is striving to protect human health and the environment from adverse impacts resulting from acts of terror by investigating the effectiveness and applicability of technologies for homeland security (HS)-related applications. EPA has identified detection of pathogenic micro-organisms in environmental samples following a terrorist attack as a critical component of an effective response. Detection of such pathogens would require development and validation of sampling techniques that could be used by multiple laboratories following a homeland security event. The Centers for Disease Control and Prevention (CDC), part of the U.S. Department of Health and Human Services (DHHS), has extensive knowledge of potential biological hazards. In this book, CDC, in collaboration with EPA, developed and improved methods for extraction of Bacillus anthracis (BA) spores from soil. This book also investigates the efficacy of four chemical decontaminants for inactivating Bacillus anthracis (causative agent for anthrax) spores in soil.

E.coli - Environmental Health Issues of VTEC 0157 (Hardcover): Stephen Palmer, Sharon Parry E.coli - Environmental Health Issues of VTEC 0157 (Hardcover)
Stephen Palmer, Sharon Parry
R3,168 Discovery Miles 31 680 Ships in 10 - 15 working days


The control of E.coli 0157 is at the heart of the environmental health practitioner's professional agenda. This book is aimed at health professionals who need to be fully informed about the sources and effects of the organism in order to provide advice and enforce legislation at local level as well as providing non specialist professionals with a practical introduction to the terminology, methods and issues surrounding the diagnosis and control of E.coli.

eBook available with sample pages: 0203302710

Natural Antimicrobial Agents (Hardcover, 1st ed. 2018): Jean-Michel Merillon, Celine Riviere Natural Antimicrobial Agents (Hardcover, 1st ed. 2018)
Jean-Michel Merillon, Celine Riviere
R3,938 R3,269 Discovery Miles 32 690 Save R669 (17%) Ships in 10 - 15 working days

Documenting the latest research in the field of different pathogenic organisms, this book presents the current scenario about promising antimicrobials in the following areas: Part I. Plants as source of antibacterials, Part II. Naturally occurring antifungal natural products, Part III. Antiparasitic natural products, Part IV. Antiviral natural products. Renowned scientists from the globe have been selected as authors to contribute chapters. Use of plants for various ailments is as old as human civilization and continuous efforts are being made to improve medicinal plants or to product their bioactive secondary metabolites in high amounts through various technologies. About 200,000 natural products of plant origin are known and many more are being identified from higher plants and micro-organisms. Some plants based drugs are used since centuries and there is no alternative medicine for many such drugs as cardiac glycosides. Drug discovery from medicinal plants or marine micro-organisms continues to provide an important source of new drug leads. Research on new antibacterials represents a real and timely challenge of this century, particularly for the treatment of infections caused by clinical isolates that show multidrug resistance. The main microorganisms involved in the resistance process have been identified and given the acronym ESKAPE for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa and Enterobacteriaceae. Multidrug resistant Mycobacterium tuberculosis including highly drug-resistant strains (XDR-TB) has also emerged as one of the most important clinical challenges of this century. Plants of diverse taxa and marine micro-organisms are rich source of these antimicrobials. An attempt has been made to compile the recent information about natural sources of antibacterials and their sustainable utilization. Increased panic of these pathogens warrants a growing demand for research to undertake the threat of multidrug resistance. The search for new antifungal, antiparasitic and antiviral natural products is far from devoid of interest. According to the WHO report in 2013, malaria still represents some 207 million cases worldwide and more than 3 billion of people are still exposed to this risk. Similarly, about 350 million people are considered at risk of contracting leishmaniasis. The fight against some viruses also requires that the research on natural products continue. For example, even if an antiretroviral with direct action was recently approved in Europe in 2013, its high cost does not allow to offer it to an exposed population in countries where the cost of drugs remains a problem for a large part of the population. These books are useful to researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.

Bio-valorization of Waste - Trends and Perspectives (Hardcover, 1st ed. 2021): Shachi Shah, V. Venkat Ramanan, Ramprasad Bio-valorization of Waste - Trends and Perspectives (Hardcover, 1st ed. 2021)
Shachi Shah, V. Venkat Ramanan, Ramprasad
R4,220 Discovery Miles 42 200 Ships in 7 - 11 working days

This book explores the concept and methods of waste management with a new approach of biological valorization. Waste valorization is a process that aims to reduce, reuse, and recycle the waste into usable, value-added, and environmental benign raw materials which can be a source of energy. The book brings together comprehensive information to assert that waste can be converted into a resource or a raw material for value addition. Waste valorization imbibes the natural recycling principles of zero waste, loop closing, and underlines the importance of sustainable and environmentally friendly alternatives. Drawing upon research and examples from around the world, the book is offering an up-to-date account, and insight into the contours of waste valorization principles, biovalorization technologies for diverse group of wastes including agricultural, municipal, and industrial waste. It further discusses the emerging paradigms of waste valorization, waste biorefineries, valorization technologies for energy, biofuel, and biochemical production. The book meets the growing global needs for a comprehensive and holistic outlook on waste management. It is of interest to teachers, researchers, scientists, capacity builders and policymakers. Also, the book serves as additional reading material for undergraduate and graduate students of biotechnology and environmental sciences.

Methods in Practical Laboratory Bacteriology (Paperback): Henrik Chart Methods in Practical Laboratory Bacteriology (Paperback)
Henrik Chart
R4,775 Discovery Miles 47 750 Ships in 10 - 15 working days

The success of laboratory experiments relies heavily on the technical ability of the bench scientist, with the aid of "tricks-of-the-trade", to generate consistent and reliable data. Regrettably, however, these invaluable "tricks-of-the-trade" are frequently omitted from scientific publications. This paucity of practical information relating to the conduct of laboratory bacteriology experiments creates a gaping void in the pertinent literature.
Methods in Practical Laboratory Bacteriology fills this void. It provides detailed technical information that ensures that you achieve consistent and reliable data. The book addresses the aspects of bacterial fractionation and membrane characterization, the analysis of Lipopolysaccharides and the techniques of SDS-PAGE, immunoblotting, and ELISA. It also describes the methods used for detecting and quantifying bacterial resistance to antibiotics, and the analysis of bacterial chromosomes by pulsed-field gel electrophoresis (PFGE). Methods in Practical Laboratory Bacteriology also covers protocols for extracting the fingerprinting plasmids, as well as the use of non-radio labeled gene probes and ribosomal RNA gene probes.

Bacteria: A Very Short Introduction (Paperback): Sebastian G. B Amyes Bacteria: A Very Short Introduction (Paperback)
Sebastian G. B Amyes
R231 R191 Discovery Miles 1 910 Save R40 (17%) Ships in 10 - 15 working days

Bacteria form a fundamental branch of life. They are the oldest forms of life as we know it, and they are still the most prolific living organisms. They inhabit every part of the Earth's surface, its ocean depths, and even terrains such as boiling hot springs. They are most familiar as agents of disease, but benign bacteria are critical to the recycling of elements and all ecology, as well as to human health. In this Very Short Introduction, Sebastian Amyes explores the nature of bacteria, their origin and evolution, bacteria in the environment, and bacteria and disease. In looking at our efforts to manage co-evolving bacteria, he also considers the challenges of resistance to antibiotics. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Bergey's Manual of Systematic Bacteriology - Volume 2 : The Proteobacteria (Book, 2nd ed. 2005): George M. Garrity Bergey's Manual of Systematic Bacteriology - Volume 2 : The Proteobacteria (Book, 2nd ed. 2005)
George M. Garrity
R9,915 Discovery Miles 99 150 Ships in 7 - 11 working days

Bergey's Manual of Systematic Bacteriology, one of the most comprehensive and authoritative works in the field of bacterial taxonomy, has been extensively revised in the form of a 5 volume Second Edition. Since the first edition was published in 1984, the field has undergone explosive growth, with over 2200 new species and 390 new genera having been described. Numerous taxonomic rearrangements and changes in nomenclature have resulted from more than 850 published new combinations. These developments, which are attributable to rapid advances in molecular sequencing of highly conserved regions of the procaryotic genome, most notably genes coding for the RNA of the small ribosomal subunit, have lead to a natural classification that reflects the evolutionary history of Bacteria and Archaea, and to the development of new, universally applicable methods of identifying these organisms. This new edition has been completely reorganized along phylogenetic lines to reflect the current state of procaryotic taxonomy but still maintains the familiar layout of the First Edition. In addition to the detailed treatments, provided for all of the validly named and well-known species of procaryotes, new ecological information and more extensive introductory chapters have been added. Use of the manual is aided by a system of cross referencing between the phylogenetic groups and the phenotypic groups used in the First Edition. In keeping with the tradition of the First Edition, volumes will be available individually, and eventually as a complete set. The editors for Vol. 2 are Don J. Brenner of the Centers for Disease Control & Prevention, Noel R. Krieg of Virginia Polytechnic Institute, and James T. Staley of the University of Washington.

Metagenomic Systems Biology - Integrative Analysis of the Microbiome (Hardcover, 1st ed. 2020): Shailza Singh Metagenomic Systems Biology - Integrative Analysis of the Microbiome (Hardcover, 1st ed. 2020)
Shailza Singh
R3,610 Discovery Miles 36 100 Ships in 7 - 11 working days

The book serves as an amalgamation of knowledge and principles used in the area of systems and synthetic biology, and targets inter-disciplinary research groups. The readers from diversified areas would be benefited by the valuable resources and information available in one book. Microbiome projects with efficient data handling can fuel progress in the area of microbial synthetic biology by providing a ready to use plug and play chassis. Advances in gene editing technology such as the use of tailor made synthetic transcription factors will further enhance the availability of synthetic devices to be applied in the fields of environment, agriculture and health. The different chapters of the book reviews a broad range of topics, including food microbiome in ecology, use of microbiome in personalized medicine, machine learning in biomedicine. The book also describes ways to harness and exploit the incredible amounts of genomic data. The book is not only limited to medicine but also caters to the needs of environmentalists, biochemical engineers etc. It will be of interest to advanced students and researchers in life sciences, computational biology, microbiology and other inter-disciplinary areas.

Prokaryotic Metabolism and Physiology (Hardcover, 2nd Revised edition): Byung Hong Kim, Geoffrey Michael Gadd Prokaryotic Metabolism and Physiology (Hardcover, 2nd Revised edition)
Byung Hong Kim, Geoffrey Michael Gadd
R3,250 Discovery Miles 32 500 Ships in 10 - 15 working days

Vast numbers of different prokaryotic microorganisms shape the biosphere, with diverse metabolic capabilities. Determination of genome sequences for a wide range of bacteria and archaea now requires an in-depth knowledge of prokaryotic metabolic function to give biochemical, physiological and ecological meaning to the genomic information. This new edition describes up-to-date knowledge of the key metabolic processes that occur under different conditions, and the cellular processes that determine prokaryotic roles in the environment, biotechnology and human health. Essential for students of microbiology, applied microbiology, biotechnology, genomics and systems biology, this advanced textbook covers prokaryotic structure, composition, nutrient transport, biosynthesis and growth. Newly characterised metabolic pathways are included, as well as the latest understanding of metabolic regulation and stress responses. Additionally, the link between energetics, growth and survival is discussed as well as the maintenance of genetic integrity by the bacterial immune system.

Protein Aggregation in Bacteria - Functional and Structural Properties of Inclusion Bodies in Bacterial Cells (Hardcover):... Protein Aggregation in Bacteria - Functional and Structural Properties of Inclusion Bodies in Bacterial Cells (Hardcover)
Silvia Maria Doglia, Marina Lotti
R2,659 R2,516 Discovery Miles 25 160 Save R143 (5%) Ships in 10 - 15 working days

Focuses on the aggregation of recombinant proteins in bacterial cells in the form of inclusion bodies and on their use in biotechnological and medical applications The first book devoted specifically to the topic of aggregation in bacteria, Protein Aggregation in Bacteria: Functional and Structural Properties of Inclusion Bodies in Bacterial Cells provides a large overview of protein folding and aggregation, including cell biology and methodological aspects. It summarizes, for the first time in one book, ideas and technical approaches that pave the way for a direct use of inclusion bodies in biotechnological and medical applications. Protein Aggregation in Bacteria covers: * Molecular and cellular mechanisms of protein folding, aggregation, and disaggregation in bacteria * Physiological importance and consequences of aggregation for the bacterial cell * Factors inherent to the protein sequence responsible for aggregation and evolutionary mechanisms to keep proteins soluble * Structural properties of proteins expressed as soluble aggregates and as inclusion bodies within bacterial cells both from a methodological point of view and with regard to their similarity with amyloids * Control of the structural and functional properties of aggregated proteins and use thereof in biotechnology and medicine Protein Aggregation in Bacteria is ideal for researchers in protein science, biochemistry, bioengineering, biophysics, microbiology, medicine, and biotechnology, particularly if they are related with the production of recombinant proteins and pharmaceutical science.

Green Synthesis of Nanoparticles: Applications and Prospects (Hardcover, 1st ed. 2020): Quaiser Saquib, Mohammad Faisal,... Green Synthesis of Nanoparticles: Applications and Prospects (Hardcover, 1st ed. 2020)
Quaiser Saquib, Mohammad Faisal, Abdulaziz A. Al-Khedhairy, Abdulrahman A. Alatar
R5,244 Discovery Miles 52 440 Ships in 7 - 11 working days

This book describes various strategies for the synthesis of green nanoparticles using plant extracts and microbes, including the advantages and disadvantages of different methods and their applications. After discussing strategies for and the potential of green synthesis of noble metal nanoparticles, it highlights the role of the solvent system. The book then explores the stability/toxicity of nanoparticles and the associated-surface engineering techniques for achieving biocompatibility, and examines the antimicrobial efficacy of green nanoparticles with regard to various bacterial pathogens, as well as the underlying cytotoxicity mechanisms. Lastly, the book addresses the potential applications of various green nanoparticles in cancer theranostics, and reviews a number of plant-mediated nanoparticles as potential pharmaceutical agents. Given its scope, the book will be of interest to all scientists and students wanting to learn more about the synthesis and applications of green nanoparticles.

Bacterial Resistance to Antibiotics - From Molecules to Man (Paperback): Boyan B. Bonev, Nicholas M. Brown Bacterial Resistance to Antibiotics - From Molecules to Man (Paperback)
Boyan B. Bonev, Nicholas M. Brown
R943 Discovery Miles 9 430 Ships in 10 - 15 working days

AN AUTHORITATIVE SURVEY OF CURRENT RESEARCH INTO CLINICALLY USEFUL CONVENTIONAL AND NONCONVENTIONAL ANTIBIOTIC THERAPEUTICS Pharmaceutically-active antibiotics revolutionized the treatment of infectious diseases, leading to decreased mortality and increased life expectancy. However, recent years have seen an alarming rise in the number and frequency of antibiotic-resistant "Superbugs." The Centers for Disease Control and Prevention (CDC) estimates that over two million antibiotic-resistant infections occur in the United States annually, resulting in approximately 23,000 deaths. Despite the danger to public health, a minimal number of new antibiotic drugs are currently in development or in clinical trials by major pharmaceutical companies. To prevent reverting back to the pre-antibiotic era--when diseases caused by parasites or infections were virtually untreatable and frequently resulted in death--new and innovative approaches are needed to combat the increasing resistance of pathogenic bacteria to antibiotics. Bacterial Resistance to Antibiotics - From Molecules to Man examines the current state and future direction of research into developing clinically-useful next-generation novel antibiotics. An internationally-recognized team of experts cover topics including glycopeptide antibiotic resistance, anti-tuberculosis agents, anti-virulence therapies, tetracyclines, the molecular and structural determinants of resistance, and more. Presents a multidisciplinary approach for the optimization of novel antibiotics for maximum potency, minimal toxicity, and appropriated degradability Highlights critical aspects that may relieve the problematic medical situation of antibiotic resistance Includes an overview of the genetic and molecular mechanisms of antibiotic resistance Addresses contemporary issues of global public health and longevity Includes full references, author remarks, and color illustrations, graphs, and charts Bacterial Resistance to Antibiotics - From Molecules to Man is a valuable source of up-to-date information for medical practitioners, researchers, academics, and professionals in public health, pharmaceuticals, microbiology, and related fields.

Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria - 2 Volume Set (Hardcover): Frans J. De Bruijn Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria - 2 Volume Set (Hardcover)
Frans J. De Bruijn
R11,000 R10,277 Discovery Miles 102 770 Save R723 (7%) Ships in 10 - 15 working days

Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable cross-talk between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.

Microbial Communication - Mathematical Modeling, Synthetic Biology and the Role of Noise (Hardcover, 1st ed. 2020): Sarangam... Microbial Communication - Mathematical Modeling, Synthetic Biology and the Role of Noise (Hardcover, 1st ed. 2020)
Sarangam Majumdar, Sisir Roy
R4,214 Discovery Miles 42 140 Ships in 7 - 11 working days

This book introduces the concept of bacterial communication systems from a mathematical modeling point of view. It sheds light on the research undertaken in the last three decades, and the mathematical models that have been proposed to understand the underlying mechanism of such systems. These communication systems are related to quorum sensing mechanisms and quorum sensing regulated processes such as biofilm formation, gene expression, bioluminescence, swarming and virulence. The book further describes the phenomenon of noise, and discusses how noise plays a crucial role in gene expression and the quorum sensing circuit operationusing a set of tools like frequency domain analysis, power spectral density, stochastic simulation and the whitening effect. It also explores various aspects of synthetic biology (related to bacterial communication), such as genetic toggle switch, bistable gene regulatory networks, transcriptional repressor systems, pattern formation, synthetic cooperation, predator-prey synthetic systems, dynamical quorum sensing, synchronized quorum of genetic clocks, role of noise in synthetic biology, the Turing test and stochastic Turing test.

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