Fungal infections have taken a new spectrum due to the increased incidence of multi-drug resistant fungal pathogens. Freedom of choice for drugs to treat fungal infections is also narrow because of lesser probability of discovering drugs that would bypass affecting human cells and target fungal cells producing fewer side effects in patients. An approach has gained prominence in research is to look for bioactive antifungal compounds from natural to synthetic sources. It is necessary to discover new classes of antifungals to control the recent emergence of multi-drug resistant fungal infections. This book proposed a details top to bottom outline of antifungal compounds derived naturally or synthetically. The details of their modifications or synthetic analogues have been described, helpful to understand the structure-activity relationship which leads to new compound development in antifungal chemotherapy. Each chapter begins with a comprehensive, top-bottom in-depth discussion of antifungal agents with updated bibliographic references. This compendium will serve as a companion not only for Scientists, Researchers, and Professors, Medical Practitioners but also a valuable reference text for the university students.

An emerging theme in molecular and cellular microbiology has been the ability of many pathogens to usurp the host cell and eventually colonize the host. This interaction between bacteria and host is not unidirectional - both pathogens and host cells engage in a signalling cross-talk. Research focused on this cross-talk and discussed in this volume, reveals not only novel aspects of bacterial pathogenesis, but also key information about epithelial biology with broader implications in the prevention and treatment of infectious diseases. Written by leading researchers in this field, this book provides a valuable overview of the host-bacterial interactions that occur at mucosal surfaces including the gastrointestinal, respiratory, and urogenital tracts. It will therefore be a valuable resource for graduate students and researchers working on these systems or in the fields of molecular and cellular microbiology or infectious disease medicine.

This book provides up-to-date information on the crucial interaction of pathogenic bacteria and professional phagocytes, the host cells whose purpose is to ingest, kill, and digest bacteria in defense against infection. The introductory chapters focus on the receptors used by professional phagocytes to recognize and phagocytose bacteria, and the signal transduction events that are essential for phagocytosis of bacteria. Subsequent chapters discuss specific bacterial pathogens and the strategies they use in confronting professional phagocytes. Examples include Helicobacter pylori, Streptococcus pneumoniae, and Yersinae, each of which uses distinct mechanisms to avoid being phagocytosed and killed. Contrasting examples include Listeria monocytogenes and Mycobacterium tuberculosis, which survive and replicate intracellularly, and actually cooperate with phagocytes to promote their entry into these cells. Together, the contributions in this book provide an outstanding review of current knowledge regarding the mechanisms of phagocytosis and how specific pathogenic bacteria avoid or exploit these mechanisms.

This compendium reviews different processes acting on bacterial groups that evolved one or more relationships with members of the most important invertebrate Phyla. Starting from principles of basic bacteriology the book provides data on bacteria interactions with pests, animal or human diseases. Being present in all environments, from deep see to crops, animals or plants, invertebrates represent the most significant and ancient fraction of the eukaryotic biomass on earth. Their evolutive adaptations and links with bacteria, established over time scales of ages, range from vectored diseases to speciation, within a wide range of environmental niches and biocenosis, including oceanic hydrothermal vents. Main functional processes include pathogenicity, parasitism, transmission, immunity, symbiosis and speciation. A review about recent advances achieved in these research topics is given, focussing on one or more aspects concerning significant evolutive paths of bacteria and underlying functional links. Rather than proceeding through the order and structure of taxonomies, the volume is organized by processes, examining their functional role in different lineages, including but not limited to insects or nematodes. Processes involved in parasitism focus, at a finer level, on examples from many taxa. Molecular aspects underpinning these and other functional processes include the effects of horizontal gene transfer, the mechanisms active in immune defense and vectoring, and the antibacterial peptides. Finally, the effects of climate warming, biological invasions and agriculture are examined, with particular attention to farming and environment.

This book provides all facets of acetic acid bacteria (AAB) and offers the future targets and directions of AAB research. It summarizes the distinctive physiological properties of AAB and the recent progress on AAB study, especially in the following five areas: 1) Molecular phylogeny and genome study of AAB; 2) Ecological features of AAB: interaction with plants, natural fermentation systems, and insects; 3) Physiological features and living strategies of AAB, including rapid oxidation ability, acid resistance, biofilm formation, and genetic instability; 4) Molecular mechanisms of several oxidative fermentations such as acetate fermentation, sorbose fermentation, and ketogluconate fermentation; 5) Recent biotechnological aspects of AAB: biocatalysts, biosensors, biocellulose, and other useful polysaccharides. AAB research has a long history since the discovery of AAB by Louis Pasteur and the identification of AAB by Martinus Beijerinck in the nineteenth century. In the twentieth century, basic research on the taxonomic study of AAB and on biochemical study for the unique oxidative reactions of AAB had progressed as well as the industrial application of AAB not only in vinegar fermentation but also in the bioconversion process for useful chemical or pharmaceutical products. Entering the twenty-first century, AAB research has expanded more, and further progress is expected to be seen in all fields of AAB: classification and ecology, physiology and biochemistry, genetics, and biotechnology of vinegar fermentation and other oxidative fermentations. Far-reaching development in the last decade makes these bacteria more valuable for various industrial uses. Readers can obtain useful and comprehensive information which is exciting in aspects of basic science and provides hints for the better application of these bacteria to various kinds of practical production scenarios as well.

Ninety percent of the cells in the human body are bacteria, and humans may be host to many thousands of different species of bacteria. These striking statistics are part of a new paradigm in microbiology in which bacteria are no longer viewed as disease-causing killers but more as lifelong partners which are often essential for the survival of their host. This book brings together a group of diverse scientists - evolutionary biologists, immunologists, molecular biologists, microbiologists, pathologists and mathematicians - to discuss the evolution and mechanisms of bacteria-host interactions at all levels of complexity. Chapters deal with the evolution of these interactions over the last 60 years (since the introduction of antibiotics) to a period of 3.8 billion years (since the evolution of single-celled life) and discuss bacterial interactions with multicellular life forms from coral reefs to humans. Researchers and graduate students across the life sciences will find this book of interest.

This volume provides detailed discussion of a variety of important techniques that researchers use to study fungal molecular biology and pathogenesis. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Candida Species: Methods and Protocols aims to ensure successful results in the further study of this vital field.

This volume presents a comprehensive collection of methods that have been instrumental to the current understanding of bacterial persisters. Chapters in the book cover topics ranging from general methods for measuring persister levels in Escherichia coli cultures, protocols for the determination of the persister subpopulation in Candida albicans, quantitative measurements of Type I and Type II persisters using ScanLag, to in vitro and in vivo models for the study of the intracellular activity of antibiotics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Persistence: Methods and Protocols brings together the most respected researchers in bacterial persistence whose studies will remain vital to understanding this field for many years to come.

Handbook of Algal Science, Microbiology, Technology and Medicine provides a concise introduction to the science, biology, technology and medical use of algae that is structured on the major research fronts of the last four decades, such as algal structures and properties, algal biomedicine, algal genomics, algal toxicology, and algal bioremediation, algal photosystems, algal ecology, algal bioenergy and biofuels. It also covers algal production for biomedicine, algal biomaterials, and algal medicinal foods within these primary sections. All chapters are authored by the leading researchers in their respective research fields. Our society currently faces insurmountable challenges in the areas of biomedicine and energy in the face of increasing global population and diminishing natural resources as well as the growing environmental and economic concerns, such as global warming, greenhouse gas emissions and climate change. Algae offer a way to deal with these challenges and concerns for both sustainable and environment friendly bioenergy production and in biomedicine through the development of crucial biotechnology.

Fire Blight is a bacterial disease that is particularly destructive to apple and pear trees, but which also attacks other plants, including woody ornamentals such as pyracantha or cotoneaster It is a significant disease in all temperate regions of the world and is of major quarantine significance. Historically, it has also played a major role in the development of the subject of bacterial plant pathology, as the pathogen, erwinia amylovora, has been used as a model organism for studies on plant pathogenic bacteria This work is divided into three parts. The first addresses the disease, including its epidemiology, distribution, host range, detection and infection The second considers the pathogen, including its biochemistry, genetics and pathogenicity. The final part reviews control, including chemical and biological methods, breeding for resistance, the use of transgenic plants and prediction modelling Written by leading research workers from the USA, Europe and New Zealand, it is a reference aimed at students, research workers and advisors in bacteriology, plant pathology and horticulture.

Cyanobacteria have existed for 3.5 billion years, yet they are still the most important photosynthetic organisms on the planet for cycling carbon and nitrogen. The ecosystems where they have key roles range from the warmer oceans to many Antarctic sites. They also include dense nuisance growths in nutrient-rich lakes and nitrogen-fixers which aid the fertility of rice-fields and many soils, especially the biological soil crusts of arid regions. Molecular biology has in recent years provided major advances in our understanding of cyanobacterial ecology. Perhaps for more than any other group of organisms, it is possible to see how the ecology, physiology, biochemistry, ultrastructure and molecular biology interact. This all helps to deal with practical problems such as the control of nuisance blooms and the use of cyanobacterial inocula to manage semi-desert soils. Large-scale culture of several organisms, especially "Spirulina" ("Arthrospira"), for health food and specialist products is increasingly being expanded for a much wider range of uses. In view of their probable contribution to past oil deposits, much attention is currently focused on their potential as a source of biofuel.

Please visit http: //extras.springer.com/to view Extra Materials belonging to this volume.

Thisbook complements thehighly successful "Ecology of Cyanobacteria" and integrates the discoveries of the past twelve years with the older literature.

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Bacterial spores are the most resistant and dormant forms of life on earth. Therefore, they are of great fundamental interest. They are the targets for inactivation in some of the largest food and pharmaceutical industries on earth, and are of great practical importance. Many research groups around the world have attempted to unravel the spore's mechanisms of resistance, dormancy and germination. Although complete understanding has not yet been achieved, substantial advances have been made in recent years. The most important of these advances are summarized here by scientists in the forefront of their particular areas of expertise. This volume will be of value to research microbiologists, geneticists, biochemists and physicists who are interested in the fundamentals of the biochemical and physical basis of resistance and dormancy, and in spore science more generally. It will also be of value to those scientists who are concerned with the thoroughly practical problems of spore destruction and control in the food and pharmaceutical industries and in public health.

As doctors and biologists have learned, to their dismay, infectious disease is a moving target: new diseases emerge every year, old diseases evolve into new forms, and ecological and socioeconomic upheavals change the transmission pathways by which disease spread. By taking an approach focused on the general evolutionary and ecological dynamics of disease, this Very Short Introduction provides a general conceptual framework for thinking about disease. Ecology and evolution provide the keys to answering the 'where', 'why', 'how', and 'what' questions about any particular infectious disease: where did it come from? How is it transmitted from one person to another, and why are some individuals more susceptible than others? What biochemical, ecological, and evolutionary strategies can be used to combat the disease? Is it more effective to block transmission at the population level, or to block infection at the individual level? Through a series of case studies, Benjamin Bolker and Marta L. Wayne introduce the major ideas of infectious disease in a clear and thoughtful way, emphasising the general principles of infection, the management of outbreaks, and the evolutionary and ecological approaches that are now central to much research about infectious disease. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Recent outbreaks of fatal food-borne illness associated with Vero cytotoxin-producing E.Coli (VTEC) have highlighted the need for thorough and coherent information to be provided to the food industry.

The book details the causes of selected incidents and assesses the lessons that can be learnt from them. It examines the characteristics of E.Coli and VTEC and identifies factors which make foods susceptible to contamination by these pathogens. Specific product sectors are used to indicate practical measures that can be applied to control VTEC in foods and minimise its potential to cause harm to the consumer. It also provides guidance in selecting effective sampling plans and test methods to monitor and detect the organism and offers pragmatic advice on action taken when the organism is detected during monitoring programmes.

This information is designed for use by the food industry, particularly personnel working in manufacturing, safety and quality control. It will also be useful for Environmental Health Officers and food research institutions.

Viral, Parasitic, Bacterial, and Fungal Infections: Antimicrobial, Host Defense, and Therapeutic Strategies highlight diverse types of infections, including viral, bacterial, parasitic, fungal, and the therapeutic efficacy of antibiotics, antivirals, antifungals and other medications, nutraceuticals, and phytotherapeutics. This book addresses the molecular, pathophysiological, and cellular pathways involved in the process of infection. It also examines the host defense mechanisms modulated by innate and adaptive immunity. The book starts off with an introduction, which includes etiology, pathophysiology, and diagnosis of infections. It then goes on to cover a wide spectrum of salient features involved in viral, bacterial, parasitic, and fungal infections and effective therapeutic strategies. In addition, there is a complete section of eight chapters elaborating the detailed aspects of COVID-19 infections, Mucormycosis, Omicron, and strategic vaccines and therapeutics. The book further goes on to discuss novel antibiotics, vaccines, bromhexine, boron compounds, phytotherapeutics, and aspects on boosting immune competence. Contributed by experts in the fields of viral, parasitic, bacterial, and fungal infections, the book comprehensively details the various types of infections such as herpes and COVID-19, their molecular mechanisms, and treatment strategies for those engaged in the research of infectious diseases.

This updated book explores a wide repertoire of tools and approaches that have been created, modified, and applied to the study of L. monocytogenes, forming the basis of our understanding of the bacterium today. Many of these key experimental techniques are gathered together herein. The volume presents aspects such as clinical disease and host-pathogen interactions, as well as the study of biofilms which present a significant challenge for control of the organism in the food processing environment. The topics covered in this edition also include sampling in order to isolate Listeria, methods for their identification and characterization, methods for gene manipulation, and methods for control of the organism. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Listeria monocytogenes: Methods and Protocols, Second Edition aims to contribute toward the harmonization of methods used to study this important bacterium, and to be of particular interest to Listeria research both in relation to food association and control as well as clinical microbiology.

Mycobacteria are bacterial pathogens which cause diseases in humans and non-human animals. This monograph primarily covers the most important and widely researched groups of mycobacteria: members of the Mycobacterium tuberculosis complex (MTC) and Mycobacterium leprae, across a wide range of host species. M. tuberculosis and M. bovis are particularly relevant with the increasing drug resistance and co-infection with HIV associated with M. tuberculosis and the possible cross-infection of badgers and cattle associated with M. bovis. This book provides a reference for researchers working in different fields, creating a work which draws together information on different pathogens, and by considering the diseases in a zoonotic context, provides a One Health approach to these important groups of diseases.

Inspired by the pace of change in the taxonomy of the aerobic endospore-forming bacteria, the "Bacillus 2000" symposium on which this book is based was held in Bruges, Belgium, in August 2000, and was supported by the Federation of European Microbiological Societies, the Belgian Society for Microbiology, and several commercial sponsors. Bringing taxonomists interested in Bacillus and its relatives together with people who work with these organisms in medicine, agriculture, and industry, allowed those attending to appreciate the overlaps and interactions of their areas of expertise, in the absence of any comprehensive treatment of the current systematics of the group.

The meeting was a great success, and has resulted in the production of these proceedings, Applications and Systematics of Bacillus and Relatives, providing an up-to-date and comprehensive treatise on the classification, identification and applications of the aerobic endospore-forming bacteria; it is an essential reference for all microbiologists interested in these organisms.
Valuable reference work for all those interested in the systematics of Bacillus and its relatives.
Produced in response to the successful Bacillus 2000 meeting in Bruges and was supported by the Federation of European Microbiological Societies, the Belgian Society for Microbiology, and several commercial sponsors.
Of use to those working in fields as diverse as medicine, agriculture, food and industry.
Comprehensive and up-to-date analysis of the systematics of these organisms.
Includes the application of sophisticated chemotaxonomic and genetic characterization methods.

A collection of 17 reproduced typescripts, most double spaced, without introduction or preface. The topics include a comparison of conventional typing with molecular typing of recent isolates of group B Streptococci from the UK, identifying a common structural binding domain in fibronectin-binding p

This practical book provides an updated resource for the identification of bacteria found in animals inhabiting the aquatic environment, illustrated with colour photos. It contains expanded biochemical identification tables to include newly identified pathogenic and saprophytic bacteria, molecular identification tests now available for a greater number of aquatic bacterial pathogens, more information on the pathogenesis and virulence of each organism and new coverage of traditional and molecular identification of fungal pathogens and quality assurance standards for laboratories.

Rhizosphere biology is approaching a century of investigations wherein growth-promoting rhizomicroorganisms (PGPR) have attracted special attention for their ability to enhance productivity, profitability and sustainability at a time when food security and rural livelihood are a key priority. Bio-inputs - either directly in the form of microbes or their by-products - are gaining tremendous momentum and harnessing the potential of agriculturally important microorganisms could help in providing low-cost and environmentally safe technologies to farmers.One approach to such biologically-based strategies is the use of naturally occurring products such as PGPR. Advances in PGPR Research explores recent developments and global issues in biopesticide research, presented via extended case studies and up-to-date coverage of: * Low input biofertilizers and biofungicides used for sustainable agriculture. * Molecular techniques to enhance efficacy of microbial inputs. * Intellectual property issues in PGPR research. Written by an international team of experts, this book considers new concepts and global issues in biopesticide research and evaluates the implications for sustainable productivity. It is an invaluable resource for researchers in applied agricultural biotechnology, microbiology and soil science, and also for industry personnel in these areas.

Antibiotic Materials in Healthcare provides significant information on antibiotic related issues, accurate solutions, and recent investigative information for health-related applications. In addition, the book addresses the design and development of antibiotics with advanced (physical, chemical and biological) properties, an analysis of materials, in vivo and in vitro applications, and their biomedical applications for healthcare.