For the eighth time the yersiniologists all over the world gathered together when the International Symposium on Yersinia was organized by University of Turku and Turku Microbiology Society in Turku, Finland. Over 250 delegates from 28 countries attended the Symposium. The Symposium logo (Picture 4, next page) presents a bacteriophage attached to the surface of the bacterium. One can easily imagine that most of the aspects covered in this Symposium are included in the logo: the bacteriophage genome encodes for structural proteins, adhesins and effector proteins that interact with the host cell in most intricate ways to carry out their mission. Life of the bacteriophage depends on the tightly regulated interplay between the phage and the host proteins. This all is also true between Yersinia and the different hosts and environments it encounters during its life cycle. This Symposium Proceedings volume is based on the oral and poster presentations given during the Symposium. The volume has been divided into six parts covering topics such as genomics, surface structures, bacteriophages, molecular and cellular pathogenesis, molecular epidemiology and diagnostics, gene regulation, clinical aspects and vaccines. These topics reflect righteously the present trends in the bacteriology research.

A significant component of many different ecosystems, cyanobacteria occupy almost every niche of the earth, including fresh and salt waters, rice fields, hot springs, arid deserts, and polar regions. Cyanobacteria, along with algae, produce nearly half the global oxygen, making assessment of their ecophysiologies important for understanding climate impacts and potential remediation. Stress Biology of Cyanobacteria: Molecular Mechanisms to Cellular Responses is a compilation of holistic responses of cyanobacteria, ranging from ecological and physiological to the modern aspects of their molecular biology, genomics, and biochemistry. Covering almost every aspect of cyanobacterial stress biology, this book is divided into two parts: Bioenergetics and Molecular Mechanisms of Stress Tolerance and Cellular Responses and Ecophysiology. The first few chapters focus on the molecular bioenergetics of photosynthesis and respiration in cyanobacteria, and provide a clear perspective on different stress tolerance mechanisms. Part I also covers the effect of specific stresses-including heavy metal, high and low temperature, salt, osmotic, and UV-B stress-on a wide range of vital physiological, biochemical, and molecular processes of cyanobacteria. Part II describes mechanisms of symbiosis, stress-induced bioproducts, and the role of environmental factors on nitrogen fixation, which along with photosynthesis is a major contributor to the current geochemical status of the planet. The text also covers mutation and cyanobacterial adaptation, and the most widely studied cyanotoxin, microcystin, which has effects on both human and animal health. With contributions from experts around the world, representing the global importance of cyanobacteria, this book provides a broad compilation of research that deals with cyanobacterial stress responses in both controlled laboratory conditions as well as in their natural environment.

1st Prize, 'New Authored Books' category, Royal Society of Medicine and Society of Authors Medical Book Awards 2008

""Overall, I am impressed by the up-to date information content and structure provided in Bacteriology of Humans. It is truly an ecological perspective helpful for undergraduate/graduate majors in microbiology and immunology."" -American Society for Microbiology, June 2009

""Wilson provides the reader with an up-to-date, comprehensive census of the indigenous microorganisms that inhabit the human body and in so doing contributes significantly to this rapidly advancing area of study. The narrative is clearly written; the index is excellent; there are numerous bibliographic citations. Each chapter is rich with tables, diagrams, color micrographs, and charts ... Highly recommended."" -Choice Reviews

""This comprehensive, yet accessible text... is an excellent and informative reference book... it should be on the shelf of every major science and medical library. The content, organization, and presentation make this book a unique resource."" -Doody's Book Reviews

Until recently, the indigenous microbiota of humans has been a relatively neglected area of microbiology with most attention being focused on those microbes that cause disease in humans, rather than on those that co-exist with us in the disease-free state. However, in the past decade research has shown that not only is the indigenous microbiota involved in protecting humans from exogenous pathogens but it is also involved in our development and nutrition. Consequently, interest has grown substantially among health professionals and scientists in analyzing and understanding these microbial (largely bacterial) communities.

This comprehensive, yet accessible text provides an up-to-date guide to the development, composition and distribution of indigenous microbial communities of humans. With the aid of abundant colour figures, diagrams, tables and maps, it establishes links between the physicochemical factors prevailing at an anatomical site and the types of microbes to be found there. The book includes an introduction to the human-microbe symbiosis as well as an in-depth look at the main systems and organs of the human body that have an indigenous microbiota. Each chapter includes a list of references for further study.

This is an excellent and informative reference book that is useful to anyone with an interest in microbiology, medical microbiology, microbial ecology, infectious diseases, immunology, human biology, medicine, dentistry, nursing, health sciences, biomedical sciences or pharmacy - it should be on the shelf of every major science and medical library.

Hallmark Features: Provides a comprehensive, yet accessible, reference book on the human microbiotaLavishly illustrated with colour figures, diagrams, tables and mapsEach chapter provides a list of references to promote further studyEach chapter contains links to key websitesOffers an ecological approach that explains why certain organisms are associated with a particular anatomical site

Expert authors from around the world contribute comprehensive, up-to-date reviews on the current state of our knowledge of bacterial endospores.

During the past three decades there has been a large amount of research on biological nitrogen fixation, in part stimulated by increasing world prices of nitrogen-containing fertilizers and environmental concerns. In the last several years, research on plant-microbe interactions, and symbiotic and asymbiotic nitrogen fixation has become truly interdisciplinary in nature, stimulated to some degree by the use of modern genetic techniques. These methodologies have allowed us to make detailed analyses of plant and bacterial genes involved in symbiotic processes and to follow the growth and persistence of the root-nodule bacteria and free-living nitrogen-fixing bacteria in soils. Through the efforts of a large number of researchers we now have a better understanding of the ecology of rhizobia, environmental parameters affecting the infection and nodulation process, the nature of specificity, the biochemistry of host plants and microsymbionts, and chemical signalling between symbiotic partners. This volume gives a summary of current research efforts and knowledge in the field of biological nitrogen fixation. Since the research field is diverse in nature, this book presents a collection of papers in the major research areas of physiology and metabolism, genetics, evolution, taxonomy, ecology, and international programmes.

Victor Vaughan's career at the University of Michigan spanned more than four decades, beginning with his graduate studies in physiological chemistry during the 1870s and ending in 1921 with his retirement after three decades as dean of the medical school. Not only was he instrumental in modernizing medical training at Michigan, his work in areas of hygiene, epidemiology and the study of toxins and infectious disease was highly regarded on the national scene. Twice he was called upon to serve his country in times of crisis. During the Spanish-American War he was a key member of the Typhoid Commission which investigated the outbreak of the life-threatening fever among army recruits in southern camps. During World War I, he was a member of the medical board within the Council of National Defense contended with an unprecedented influenza outbreak. Vaughan's professional work included more than 250 published papers and some 17 books, many that outlined laboratory techniques which modernized the newly evolving field of bacteriology.

Salmonella: Methods and Protocols, Second Edition expands upon the previous edition with current, detailed methods on different aspects and landmarks advancing knowledge on salmonella research. With new chapters on molecular assays for detection, identification and serotyping of salmonella, quantitative proteomic identification of host factors involved in salmonella infection, determination of antimicrobial resistance in salmonella, site-directed mutagenesis, chromosomal gene analysis, development of bacterial nanoparticle vaccine, attachment of nanoparticle cargo to biotinylated salmonella for combination bacteriotherapy against tumors, various microscopy methods to analyze salmonella interaction with host cells, in vitro modeling of gallbladder-associated salmonella colonization, and analysis of salmonella phages and prophages. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Salmonella: Methods and Protocols, Second Edition present methods that are of value to investigators in the salmonella field.

"Bacterial Biogeochemistry, Third Edition" focuses on bacterial metabolism and its relevance to the environment, including the decomposition of soil, food chains, nitrogen fixation, assimilation and reduction of carbon nitrogen and sulfur, and microbial symbiosis. The scope of the new edition has broadened to provide a historical perspective, and covers in greater depth topics such as bioenergetic processes, characteristics of microbial communities, spatial heterogeneity, transport mechanisms, microbial biofilms, extreme environments and evolution of biogeochemical cycles.
Provides up-to-date coverage with an enlarged scope, a new historical perspective, and coverage in greater depth of topics of special interestCovers interactions between microbial processes, atmospheric composition and the earth's greenhouse propertiesCompletely rewritten to incorporate all the advances and discoveries of the last 20 years such as applications in the exploration for ore deposits and oil and in remediation of environmental pollution

With people living longer and longer, Dementia is now at the forefront of medical research. In answer to this changing trend, Informa Health Care and Dr. Scharre present Long-Term Management of Dementia. A stand-alone resource for diagnoses treatment and management issues for the patient suffering from dementia.

Topics covered include:

• social, legal, economic and ethical dilemmas
• functional abilities
• driving and the dementia patient
• hygiene and nutritional concerns
• supervision models
• medical complications

Neurologists, psychiatrists, geriatricians, as well as secondary caregivers, including nurses and social workers, will find, Long-Term Management of Dementia a perfect fit for health care professionals requiring a more in-depth look at this debilitating disease.

How did the Bhagavadgata first become an object of German philosophical and philological inquiry? How were its foundational concepts initially interpreted within German intellectual circles, and what does this episode in the history of cross-cultural encounter teach us about the status of comparative philosophy today? This book addresses these questions through a careful study of the figures who read, translated and interpreted the Bhagavadgata around the turn of the nineteenth century in Germany: J.G. Herder, F. Majer, F. Schlegel, A.W. Schlegel, W. von Humboldt, and G.W.F. Hegel. Methodologically, the study attends to the intellectual contexts and prejudices that framed the early reception of the text. But it also delves deeper by investigating the way these frameworks inflected the construction of the Bhagavadgata and its foundational concepts through the scholarly acts of excerpting, anthologization, and translation. Overall, the project contributes to the pluralization of Western philosophy and its history while simultaneously arguing for a continued critical alertness in cross-cultural comparison of philosophical and religious worldviews.

The importance of fungal infections in both human and animals has increased over the last few decades. This book presents an overview of the different categories of fungal infections that can be encountered in animals (including lower vertebrates) originating from environmental sources with or without transmission to humans. In addition, the endemic infections with indirect transmission from the environment, the zoophilic fungal pathogens with near-direct transmission, the zoonotic fungi that can be directly transmitted from animals to humans, mycotoxicoses and antifungal resistance in animals will also be discussed. This book includes case studies and reviews the current state of knowledge on the mechanism of fungal attraction, recognition, infection, extracellular hydrolytic enzymes and pathogenesis of nematophagous fungi. The book also covers diagnostics, fungal formulations, as well as prevention methods. It discusses strategies to access the fungal pathogen groups, metagenomic analyses, genomics, secretomics, metabolomics, proteomics and transcriptomics. In addition, pathogen description, understanding, distribution and recent research results are provided.

Neisseria meningitidis is a major causative agent, worldwide, of potentially life-threatening meningitis and septicaemia, which carry with them a high mortality rate and permanent physical and neurological issues for survivors. Neisseria meningitidis: Advanced Methods and Protocols offers a collection of methods and protocols that reflect the development and refinement of several new technologies applied to the meningococcus as presented by expert researchers. Several of the chapters in this book describe methods that rely on the collection of complete sets of biological data, for example, using the genome to generate transcriptomes, proteomes, and metabolomes. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Neisseria meningitidis: Advanced Methods and Protocols can be readily used to study other pathogens and diseases and should have broad appeal to clinical and non-clinical scientists alike; however, there is still much to learn about the meningococcus and its complex nature, which in turn continues to reveal crucial details about human biology as well.

Life on earth began with bacteria, which now colonize every corner of the planet. As the ancestors of mitochondria, bacteria are also fundamental for our cells. Most bacteria look alike, but have very different functions. Therefore, knowing the functional profile of bacteria helps understand their impact on our life. This book provides a wealth of information on the functional evolution of bacteria in a novel and coherent way. The book is aimed towards scientists as well as those who are curious about the world of bacteria and their relationships with mitochondria, the powerhouses of our cells, and us.

This book explores the broad and diverse biological and physiological impacts of established and newly discovered cyclic di-nucleotide second messenger signaling systems, while also providing descriptions of the intriguing biochemical characteristics of multiple turnover enzymes and receptors. The respective chapters discuss the commonalities and diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP signaling systems in manifold Gram-negative and Gram-positive bacteria. The global human pathogens Mycobacterium tuberculosis, Vibrio cholerae, Salmonella typhimurium, Escherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described. In turn, the various aspects of bacterial physiology affected by these signaling systems- e.g. biofilm formation and dispersal, the cell cycle, motility, virulence, production of antimicrobials, fundamental metabolism and osmohomeostasis - are discussed in detail in the context of different microorganisms. Dedicated chapters focus on the population diversity of cyclic dinucleotide signaling systems, their tendency to be horizontally transferred, the cyclic di-GMP signaling system in the social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and the development of strategies for interfering with cyclic dinucleotide signaling in order to manipulate microbial behavior. Taken together, the chapters provide an authoritative source of information for a broad readership: beginners and advanced researchers from various disciplines; individuals seeking a broad overview of cyclic di-nucleotide signaling; and those who want to learn more about specific aspects. Also featuring reviews with a forward-looking perspective, the book offers a valuable source of inspiration for future research directions.

How did the Bhagavadgata first become an object of German philosophical and philological inquiry? How were its foundational concepts initially interpreted within German intellectual circles, and what does this episode in the history of cross-cultural encounter teach us about the status of comparative philosophy today? This book addresses these questions through a careful study of the figures who read, translated and interpreted the Bhagavadgata around the turn of the nineteenth century in Germany: J.G. Herder, F. Majer, F. Schlegel, A.W. Schlegel, W. von Humboldt, and G.W.F. Hegel. Methodologically, the study attends to the intellectual contexts and prejudices that framed the early reception of the text. But it also delves deeper by investigating the way these frameworks inflected the construction of the Bhagavadgata and its foundational concepts through the scholarly acts of excerpting, anthologization, and translation. Overall, the project contributes to the pluralization of Western philosophy and its history while simultaneously arguing for a continued critical alertness in cross-cultural comparison of philosophical and religious worldviews.

Detailed information dealing with the ecology of mycobacteria is derived from a variety of different scientific fields such as botany, biochemistry, genetics, immunology, microbiology and epidemiology. This text attempts to evaluate this information from an ecological point of view and to develop a strategy for the prevention of tuberculosis and other mycobacterioses based on the ecological behaviour of mycobacteria, especially the potentially pathogenic species capable of either growth in the environment or provoking disease. Regarding the interests of the developing countries, special attention is paid to the ecology of Mycobacterium leprae and to the supporting effect of accompanying mycobacteria in its pathogenicity. On a more positive side, environmental mycobacteria play an important role in the ecology of moorland dragonflies.

One of the most important organisms in biotechnology, Corynebacterium glutamicum is currently used to produce 2 million tons of amino acids per year for a rapidly expanding market. Until now, research and information have been scattered among individual papers which are often difficult to locate in a timely manner. As the first complete compilation of major findings, Handbook of Corynebacterium glutamicum is a comprehensive source of scientific and technical information required for the understanding and manipulation of C. glutamicum. The book summarizes the current knowledge in the field ofC. glutamicum research from its discovery in 1957 through the most recent studies at the genomic and systemic level, and provides a basis for future work. Written by experts from industry and academia, chapters cover all major aspects of C. glutamicum, including physiology, biochemistry, genetics, and industrial applications. Just as C. glutamicum has proven its profitability in industry and research, this book will demonstrate its value to the scientists striving to understand and develop even more efficient producer strains of this promising microorganism.

This Microbiology Monographs volume covers the latest advances in laccase applications in bioremediation and waste valorisation. The first three chapters provide a comprehensive introduction to fungal and bacterial laccases (the two most important enzyme groups from an application viewpoint) and their practical use in bioremediation and lignocellulosic waste valorisation. Subsequent chapters discuss possible combinations of laccases and further potentially collaborating enzymes, and offer in-depth insights into laccase immobilisation for wastewater treatment and environmental biosensor applications of laccases. Lastly, the book addresses the quest for enzymes with improved and better-fitting properties, covering laccase engineering by directed and computational evolution, and novel enzymes from extreme environments. As such, it is a fascinating read for microbiologists in both industry and academia.

Numerous infectious diseases are described as idiopathic, meaning that "the cause is a complete mystery." For many idiopathic diseases, the causes become clear when certain techniques are applied to the patient's blood or other tissues. Cell Wall Deficient Forms: Stealth Pathogens, Third Edition describes these techniques. In the case of tuberculosis, a disease that has recently regained importance because the strains have acquired antibiotic resistance, the book describes a method that is widely used abroad. This method typically renders the diagnosis within 72 hours. The book examines a plethora of issues and provides answers to the following questions:
o What organism should be added to the childhood vaccine, especially for boys?
o What bacteria in its pleomorphic state is found in direct smears of synovial fluid of rheumatoid arthritis cases?
o In which chronic diseases ( presently considered as being of unknown origin) is an acid-fast organism routinely found in smears of 72 hour blood cultures?
o Which "bacterium" has a life cycle in the human erythrocyte as complex as that of Plasmodium malaria?
o Which common pathogen's L Form can permanently damage myocardium mammaliam?
Cell Wall Deficient Forms: Stealth Pathogens, Third Edition discloses significant aspects of microbiology, aspects that are not taught, and which go unrecognized in the clinical laboratory.

The objective of this book is to present a critical review and evaluation of the so-called conventional methods currently being used for bacterial identification, as well as to discuss the new approaches for the detection and identification of bacteria. Morphological, biochemical, and serological methods of detection and identification of bacteria in clinical specimens are emphasised, and current methods of characterization and enumeration of bacteria in air, water, milk, and other food materials are also described.

Spirulena Platensis, a blue-green algae, has been recognized and used worldwide as a traditional source of protein in the food industry. The uses and mass cultivation of this algae have risen substantially due to an increased understanding of its biological systems. This text contains detailed descriptions of both the biology and the biotechnological uses of Spirulena Platensis. Part One focuses on the physiology, morphology, photosyntheses and genetics of laboratory cultures. Part Two discusses the practical uses in biotechnology industries, such as: the cultivation on flat-plate reactors; mass cultures outdoors; uses in wastewater treatment and the use of biomass. It offers critiques of the problems encountered and discussions of the future commercial prospects for large-scale production.

Acinetobacter details the clinical aspects of this bacterium responsible for many infections in hospitalized patients. This reference explains the importance of these organisms, both from the patient's viewpoint and the economic perspective, and provides clinicians with the knowledge they need to control these bacteria.

The abundance of sulfate-reducing bacteria and archaea (SRBA) is impressive and new isolates are being reported continuously. A few decades ago, only two genera of sulfate-reducing bacteria (SRB) had been identified. As of 2018, 92 genera containing more than 420 species of SRB have been isolated and characterized and there are several species of archaea. This book addresses the development of the research with SRBA and includes historical background of this field. Biochemical characterization of the enzymes, cytochromes and electron carriers involved with dissimilatory sulfate reduction are reviewed and the presence of relevant genes in cultured and uncultured SRBA are assessed using genome analysis. The contributions of transmembrane electron transport complexes as related to cell energetics are discussed. This book highlights the unique cellular and molecular features of the SRBA and discusses the biochemical interactions behind their metabolic capabilities which enable SRBA to grow in extreme environments. Examples are provided to detoxify and alleviate pollution situations, to evaluate mechanisms proposed for corrosion of ferrous metals and to examine the effects of SRB on human and animal hosts.

This volume describes the structure and function of bacterial toxins and presents a comprehensive review of virulence factors, providing recent information concerning cell physiology and biochemistry, as well as new toxin tools for experimental studies and clinical therapy. A wide variety of toxic proteins, including the toxins that cause diptheria, cholera, pertussis, shigellosis, tetanus, botulism and anthrax, are discussed.;The work is aimed at microbiologists, biochemists, endocrinologists, toxicologists, infectious disease specialists, pathologists, public health officials, and upper-level undergraduate and graduate students in these disciplines.

Fimbriae are the best-studied bacterial colonization factors. They are of paramount importance in bacterial pathogenesis and microbial ecology. Due to the advent of new and powerful techniques, an impressive amount of information has been accumulated on these important surface organelles over the last decade. The first book of its kind, Fimbriae brings together into one volume the state of the art of this very active field. Internationally recognized researchers give both a horizontal and lateral approach to fimbriology. Selected types of fimbriae are extensively reviewed and fundamental questions such as evolution, control or regulation, biogenesis, bacteria-host interaction, and fimbriae-based vaccines are examined.