For systemic delivery, the oral route has been the preferred route
of administration for many systemic actively drugs. When
administered by the oral route, however, many therapeutic agents
have been reportedly subjected to extensive presystemic elimination
by gastrointestinal degradation and/or hepatic metabolism. Results
of low systemic bioavailability, short duration of therapeutic
activity, and/or formation of toxic and inactive metabolite. The
unique environment of the oral cavity offers its potential as a
site for drug delivery. Because of rich blood supply and direct
access to systemic circulation, the oral mucosal route is suitable
for drugs, which are susceptible to acid hydrolysis in the stomach
or which are extensively metabolized in the liver.
General
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