The authors have provided an overview of the relationships between
hormones that are physiologic constituents of the body as well as
their pharmacologic use in replacement therapies and related
endocrine dys function. Principles of Endocrine Pharmacology
concerns itself with the ther apeutic use of hormones, and hormone
like substances, or drugs that can act either by suppressing or
enhancing the metabolism of certain glands of internal secretion.
Other drugs used for nonendocrine ther apies can likewise affect
the endocrine system. Endocrine pharmacology emerged in the early
1900s with the use of crude pituitary extracts. By the mid-1900s
several investigators had isolated and begun to synthesize hormones
or hormonelike substances. Recognizing the limited supply of
hormones that could be obtained both from animal sources and human
autopsy material, the search for so called hormone substitutes also
began early in the 1900s. Recently, re combinant DNA technologies
have been used to provide alternative therapeutic sources of human
insulin and human growth hormone. Aside from insulin, perhaps no
other use of hormonally-active sub stance is better exemplified by
those drugs which affect fertility. The synthesis of an
orally-effective steroid represented one of the first major
breakthroughs in the chemical suppression of ovulation. Since the
orally active 19-norsteroids were introduced in the 1950s, several
oral contra ceptive steroid preparations have been marketed.
Indeed, the advent of oral contraceptives for birth control has led
to a renewed interest in endocrine pharmacology."
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