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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Antipsychotics (Paperback, Softcover reprint of the original 1st ed. 1996)
Loot Price: R2,954
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Antipsychotics (Paperback, Softcover reprint of the original 1st ed. 1996)
Series: Handbook of Experimental Pharmacology, 120
Expected to ship within 10 - 15 working days
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Antipsychotic drugs were first discovered in 1953, and not since
the late 1970s has the Handbook of Experimental Pharmacology taken
up this topic. A new treatment of this topic would be due under any
circumstances; however, this is now particularly true, since
remarkable progress has been made on several fronts in furthering
our understanding of the mechanisms of antipsychotic drug action.
First, we have learned that schizophrenia is an illness with
particu lar neuroanatomical abnormalities, many of which suggest
that the illness is caused by errors in neurodevelopment. These
findings have helped to form a context for understanding
neurochemical aberrations in the illness and suggest new approaches
for pharmacological treatment. Propelled forward by rapid advances
in neurochemical anatomy, current pathophysiological hypotheses of
schizophrenia and antipsychotic drug action have taken on the
appearance of complex electrical circuit diagrams. Second,
molecular biology studies have now revealed that there is a
multiplicity of dopamine receptors (i. e. , D , DZshort' j DZlong,
D , D , and D ), some of which may become entirely new targets for
3 4 s antipsychotic drug action. Ironically, the development of
drugs that are selec tive for these receptors and that can be used
to investigate their function lags behind; yet the discovery of
these new receptors offers unparalleled opportu nities for
developing drugs with improved efficacy and fewer side effects.
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