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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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The Promises and Challenges of Regenerative Medicine (Hardcover, 2005 ed.)
Loot Price: R3,169
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The Promises and Challenges of Regenerative Medicine (Hardcover, 2005 ed.)
Series: Ernst Schering Foundation Symposium Proceedings, 54
Expected to ship within 12 - 17 working days
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Total price: R3,189
Discovery Miles: 31 890
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Ithaslongbeenknownthatamphibiaandotherlowerordervertebrates
havethecapacitytoregeneratelimbsaswellasdamagedheartsorbrains.
Overthepastdecade,therehasbeenamajorchangeinthewaythatthe
potentialforregenerationinmammalsisviewed.Earlier,incontrastto the
acceptance of regeneration in amphibia, it was generally believed
that there was very limited if any capacity for regeneration in
many mammalianorgansystemssuchastheheartandbrain.Thediscoveryof
tissue-resident adult stem cells and the description of the
properties of embryonic stem cells have altered this view. This
change in paradigm VI Preface has led to the hope that these
discoveries can be harnessed in medical
practicetocurechronicdisablingdiseases. The use of tissue-resident
adult stem cells depends on the ability to either mobilize them or
to convert them from one lineage to another. These problems do not
arise with embryonic stem cells. Instead, their
useisfraughtwithethicalandpoliticalissuesaswellasthequestionof
howtodirecttheirdifferentiationtowardthedesiredcelltype.Whichever
approachistaken,issuesofsafetyhavetobeparamount.Inparticular,the
roleofstemcellsintumorigenesisiscriticalinassessingtheirpotential
clinicalutility. The Ernst Schering Research Foundation and the
Riken Center on
DevelopmentalBiologyjointlyorganizedaworkshopon"ThePromises
andChallengesofRegenerativeMedicine,"whichtookplaceinKobe, Japan on
20-22 October 2004. The purpose of the workshop was to discuss the
present state of knowledge and future directions in this important
?eld. Leading basic scientists and clinicians reviewed and
discussedseveraltimelytopicswithinthreemainthemes:(1)evolution,
development,andregeneration,includingstemcellsinPlanariaandstem
cell niches; (2)embryonic and adult stem cells, including
adiscussion of the regulatory system in Japan for human embryonic
stem cells; and (3) regeneration in speci?c indications including a
discussion of the role of stem cells in organs such as the skin,
brain, liver, pancreas,
cornea,andthecardiovascularsystem.Inaddition,theroleofstemcells in
glioblastoma was presented along with the implications for other
tumors.
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