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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Neurobiology of Reproduction in the Female Rat - A Fifty-Year Perspective (Paperback, Softcover reprint of the original 1st ed. 1989)
Loot Price: R2,837
Discovery Miles 28 370
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Neurobiology of Reproduction in the Female Rat - A Fifty-Year Perspective (Paperback, Softcover reprint of the original 1st ed. 1989)
Series: Monographs on Endocrinology, 32
Expected to ship within 10 - 15 working days
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It has been my privilege and pleasure during the past half century
to participate in the unfolding of present-day concepts of the
mammalian female reproductive cycles. When the studies recorded
here began in the late 1930s it was already established that cyclic
ovarian function is governed by gonadotropic secretions from the
anterior pituitary gland, the "conductor of the endrocrine
orchestra," and that in turn this activity is importantly dependent
in some way upon secretion of estro gens and progesterone by the
ovaries. Although a role of the nervous system was recognized for
the reflex-like induction of ovulation in rabbits and cats and the
in duction of pseudopregnancy in rats and mice, and although there
was even some evidence of neural participation in ovulation in
rats, a major central neural role in the female cycle of most
species was not apparent. Gonadotropic fractions of pitui tary
extracts having distinct follicle-stimulating and luteinizing
activities in test ani mals had been obtained, and these respective
effects had been fairly well charac terized. Prolactin was well
known for its lactogenic activity, but its luteotropic role in rats
and mice had yet to be revealed. The molecular structure of the
several estro gens and progesterone was known, and they were
readily available as synthetic pro ducts. The broad concept of
ovarian-pituitary reciprocity appeared to be an accept able
explanation of the female cycle, with the ovary in control through
the rhythmic rise and fall in secretion of follicular estrogen.
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