The past few years have seen considerable advances in our
understanding of the molecular basis underlying cutaneous cell
adhesion mechanisms. Co-authored by a number of leading experts in
the field DEGREESCell Adhesion and Migration in Skin Disease
provides a comprehensive overview of the critical role played by
cell adhesion in determining the structure and function of both
healthy and diseased human skin.
The book is divided into three main sections, with each one
addressing a principal function of adhesion molecules.
The first part focuses on the epidermis, which as the skin's
outermost layer, acts as the human body's primary barrier of
defence. Roles played by cytoskeletal intermediate filaments and
junctional complexes in cutaneous cell adhesion are emphasised with
descriptions of blistering skin diseases that can arise if these
molecules malfunction.
The second part describes the macromolecular interactions
responsible for the anchorage of cells to the underlying
extracellular basement membrane. The experimental approaches
detailed in the text not only reveal how the molecular components
of the dermal-epidermal junction have been elucidated, but also
highlight how mutations in the genes which encode these molecules
are responsible for many heritable skin diseases. Leukocytes
continually infiltrate the skin and patrol it for potentially
harmful pathogens. Control of leukocyte adhesion to resident cells
within the skin and to the extracellular matrix plays a key role in
controlling these processes. These mechanisms constitute the
primary focus of the final section. The pivotal role of leukocytes
is examined in conjunction with the chronic inflammatory diseases
which arise when components of the skin's finely tuned defence
strategy go awry and the potential for these anomalies to be
pinpointed as important immunotherapeutic targets for skin
diseases.
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