The aim of this work is to develop topical hydrogels containing
diclofenac potassium (DP) at 1 % w/v concentration using
conventional hydrophilic hydroxypropyl methyl cellulose (HPMC,
50cPs) and different grades of modified hydrophobic hydroxypropyl
methyl cellulose (HPMC, 60L, 60M, 90L and 90 M grade). Small
quantity of hydrophobic HPMC is good enough to prepare gel of
satisfactory quality. Hydrophobic formulations of higher viscosity
with small quantity of polymer show higher release compared to
hydrophilic formulations of lower viscosity with higher polymer
concentration. Kinetic analysis of in vitro release profile was
done by comparing the goodness-of-fit of some empirical/
semi-empirical and statistical models. From the accuracy point of
view, direct fitting is preferred to transformed linear fit
methods. Further, it was observed that the log-logistic
distribution was the best fit for hydrophobic formulations. For
hydrophilic ones, the semi-empirical models and Weibull
distribution worked best, although log-logistic also showed a close
fit. Hydrophobic formulations with enhancers are found to have the
most promising anti-nociceptive activity.
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
Germany |
Release date: |
June 2012 |
First published: |
June 2012 |
Authors: |
Kajal Ghosal
|
Dimensions: |
229 x 152 x 12mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
200 |
ISBN-13: |
978-3-659-16402-6 |
Categories: |
Books >
Medicine >
Other branches of medicine >
Pharmacology >
General
|
LSN: |
3-659-16402-X |
Barcode: |
9783659164026 |
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