Now in its second edition, this book provides a state of the art
overview on basic concepts of epigenetic epidemiology and a
comprehensive review of the rapidly evolving field of human
epigenetics. Epigenetics plays an important role in shaping who we
are and contributes to our prospects of health and disease. Unlike
our genetic inheritance, our epigenome is malleable throughout the
lifecourse and is shaped by our environmental experiences.
Population-based epidemiologic studies increasingly incorporate
epigenetic components. These so called epigenome-wide association
studies (EWAS) contribute substantially to our understanding of the
relevance of epigenetic marks, such as DNA methylation, histone
modification, and non-coding RNAs for disease causation. Written by
leading experts in the field, the book opens with a comprehensive
introduction of the principles of epigenetic epidemiology and
discusses challenges in study design, analysis, and interpretation.
It summarizes the latest advances in epigenetic laboratory
techniques, the influence of age and environmental factors on
shaping the epigenome, the epigenetic clock, and the role of
epigenetics in the developmental origins hypothesis. The final part
focuses on epigenetic epidemiology of various health conditions
such as imprinting disorders, cancer, infectious diseases,
inflammation and rheumatoid arthritis, asthma, metabolic disorder
and vascular disease, as well as neurodevelopmental and psychiatric
disorders. Given its scope, Epigenetic Epidemiology is an
indispensable resource for researchers working in the field of
human epigenetics.
General
| Imprint: |
Springer Nature Switzerland AG
|
| Country of origin: |
Switzerland |
| Release date: |
April 2023 |
| First published: |
2022 |
| Editors: |
Karin B. Michels
|
| Dimensions: |
235 x 155mm (L x W) |
| Pages: |
510 |
| Edition: |
2nd ed. 2022 |
| ISBN-13: |
978-3-03-094477-3 |
| Categories: |
Books
|
| LSN: |
3-03-094477-8 |
| Barcode: |
9783030944773 |
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