Infertility is known to us since ages. There is an alarming rate of
increase of infertility cases especially in the young urban males
in India. Keeping this in mind we took up this study to evaluate
the role of Mesterolone in oligospermic males . We also compared
the role of Mesterolone and the effects of a combined therapy of
mesterolone and clomiphene citrate on semen parameters, effect on
pituitary axis and liver function.Thirty males with idiopathic
oligospermia were included in this study. Out of the thirty
subjects,10 were given only tab mesterolone 50 mg b.d .Ten were
given 50 mg of tab mesterolone 1 b.d and 25 mg of clomiphene
citrate 1 o.d. The remaining 10 were used as controls and given tab
vitamin C 75 mg b.d for 4 months. A follow- up study was conducted
at the end of 100, 150 and 200 days for group A, B and C
respectively.A complete semen analysis including the differential
count was done. The study showed only mesterolone was not effective
in comparison to the combination of mesterolone and clomiphene
citrate which was much effective and showed 40% increase in sperm
concentration.
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