Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways
for Clinical Discovery offers a compelling and thought-provoking
perspective for the examination of the intriguing biology of
sirtuins that ties cancer and metabolic disease together and
provides a critical platform for the development of sirtuin-based
novel therapeutic strategies to effectively treat cancer and
metabolic disorders with precision in order to minimize any
potentially detrimental clinical outcomes. An exciting prospect for
the development of innovative therapeutics for cancer and metabolic
disorders involves sirtuins. Sirtuins are histone deacetylases that
have an intricate role in the onset and development of cancer and
metabolic disease. Implementing a translational medicine format,
this innovative reference highlights the ability of sirtuins to
oversee critical pathways that involve stem cell maintenance,
cellular proliferation, metabolic homeostasis, apoptosis, and
autophagy that can impact cellular dysfunction and unchecked
cellular growth that can occur during cancer and metabolic disease.
Each chapter offers an intuitive perspective of advances on the
application of sirtuin pathways for cancer and metabolic disease
that will be become a "go-to" resource for a broad audience of
scientists, physicians, pharmaceutical industry experts,
nutritionists, and students.
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