Molecular biology has driven a powerful reductionist, or
"molecule-c- tric," approach to biological research in the last
half of the 20th century. Red- tionism is the attempt to explain
complex phenomena by defining the functional properties of the
individual components of the system. Bloom (1) has referred to the
post-genome sequencing era as the end of "naive reductionism. "
Red- tionist methods will continue to be an essential element of
all biological research efforts, but "naive reductionism," the
belief that reductionism alone can lead to a complete understanding
of living organisms, is not tenable. Organisms are clearly much
more than the sum of their parts, and the behavior of complex
physiological processes cannot be understood simply by knowing how
the parts work in isolation. Systems biology has emerged in the
wake of genome sequencing as the s- cessor to reductionism (2-5).
The "systems" of systems biology are defined over a wide span of
complexity ranging from two macromolecules that interact to carry
out a specific task to whole organisms. Systems biology is
integrative and seeks to understand and predict the behavior or
"emergent" properties of complex, multicomponent biological
processes. A systems-level characteri- tion of a biological process
addresses the following three main questions: (1) What are the
parts of the system (i. e."
General
Imprint: |
HumanaPress
|
Country of origin: |
United States |
Series: |
Methods in Molecular Biology, 351 |
Release date: |
December 2010 |
First published: |
2006 |
Editors: |
Kevin Strange
|
Dimensions: |
229 x 152 x 16mm (L x W x T) |
Format: |
Paperback
|
Pages: |
292 |
Edition: |
Softcover reprint of hardcover 1st ed. 2006 |
ISBN-13: |
978-1-61737-668-9 |
Categories: |
Books >
Medicine >
Pre-clinical medicine: basic sciences >
Medical genetics
|
LSN: |
1-61737-668-X |
Barcode: |
9781617376689 |
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