Aceclofenac is an effective analgesic and anti-inflammatory drug
prescribed widely in recent years for various types of pain and
inflammation. Aceclofenac is partially insoluble in water and
aqueous fluid and as such it exhibits poor variable oral
bioavailability. Aceclofenac needs enhancement of solubility and
dissolution rate to improve its oral bioavailability and
therapeutic efficacy. Among the various approaches to enhance the
solubility and dissolution rate of poorly soluble drugs
complexation with cyclodextrin is an effective and industrially
accepted technique. In the present investigation, Complexation of
aceclofenac with -CD was carried out by using various techniques
like physical mixture, kneading method, co-precipitate method &
solvent evaporation method. From the various characterization
studies like drug content, production yield & in vitro
dissolution study. Data were further treated with statical analysis
using ANNOVA model and from the result of statical analysis batch
abc-6 by kneading method was selected as optimised batch. Optimised
batch was also studied for FTIR and DSC studies."
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