The work involves the investigation of 6 indigenous Ghanaian plants
P. pinnata, H. opposita, G. arboreum, A. nobilis, F. asperifolia
and B. aegyptiaca used for the treatment of bacterial infections
and wounds. It also describes the isolation and characterization of
the active principles from P. pinnata. Extracts were assessed for
in vitro antibacterial activity, usingwild-type and resistant
strains of Staph.aureus. P.pinnata, H. opposita, G. arboreum and F.
asperifolia showed antibacterial activity. The active compounds in
P. pinnata were isolated, using chromatographic techniques and
identified with the aid of NMR spectroscopy. The wound healing
action of the plant extracts were assessed using in vitro models.
P.pinnata, G. arboreum and F. asperifolia at concentrations from 1
to 25ug/ml had a significant stimulatory effect on the
proliferation of HDF (142BR) cells. Paullilupeol and paullilupeone
isolated from P. pinnata, showed a dose-dependent increase in
proliferation of the up to 3uM. All extracts at concentrations 1 to
50ug/ml, had a statistically significant antioxidant protective
effect against hydrogen peroxide induced damage to 142BR cells.
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
Germany |
Release date: |
2011 |
First published: |
2011 |
Authors: |
Kofi Annan
|
Dimensions: |
229 x 152 x 13mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
224 |
ISBN-13: |
978-3-8433-7169-8 |
Categories: |
Books >
Medicine >
Other branches of medicine >
Pharmacology >
General
|
LSN: |
3-8433-7169-5 |
Barcode: |
9783843371698 |
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