Potential HIV Reverse Transcriptase Inhibitors (Paperback)

The existence of CNS viral reservoirs is the main cause of recurrence of HIV infection after medication is withdrawn. This problem remains unsolved because of poor CNS penetration with the existing anti retroviral drugs. To meet the demand of crossing the blood-brain barrier (BBB) the compound should have polar surface area (PSA). PSA is defined as the surface area occupied by oxygen and nitrogen atoms and hydrogen atoms attached to these atoms. With this aspect in view, we calculated the PSA values of various substituent on the aryl rings in our aimed compounds and they were found within the prescribed limits so we proceeded with the synthesis of the compounds.

General

Imprint:	Lap Lambert Academic Publishing
Country of origin:	Germany
Release date:	July 2012
First published:	July 2012
Authors:	Komal P. Patel • Jimish R. Patel • Rajani Giridhar
Dimensions:	229 x 152 x 4mm (L x W x T)
Format:	Paperback - Trade
Pages:	68
ISBN-13:	978-3-659-18471-0
Categories:	Books > Medicine > Other branches of medicine > Pharmacology > General
LSN:	3-659-18471-3
Barcode:	9783659184710

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