This revised third edition has been updated to cover all aspects
of chiral drugs from the academic, governmental industrial and
clinical perspective reflecting the many advances in techniques and
methodology. The title will cover new material including the use of
enzymes for the synthesis and resolution of enantiomeric compounds
as well, as their use in drug discovery; how stereochemistry
impacts on decisions taken during the ADMET (absorption,
distribution, metabolism, excretion, toxicity) stage of drug
discovery; issues faced during the final stages of the drug
development process; the impact of ICH (International Conference on
Harmonisation) on the use of single isomer drugs; racemic switches;
and legal perspectives looking at IP and patent issues surrounding
chiral switches and marketing single enantiomer switches.
This Third Edition comprehensively presents all aspects of
chiral drugs from scientific, academic, governmental, industrial,
and clinical points of view. This one-stop text covers the lifespan
of stereochemistry, from its early history, including an overview
of terms and concepts, to the current drug development process,
legal and regulatory issues, and the new stereoisomeric drugs.
New topics include:
- The use of enzymes in the synthesis and resolution of
enantiometrically pure compounds in drug discovery
- How stereochemistry impacts decisions made in the Absorption,
Distribution, Metabolism, Excretion, and Toxicity (ADMET) stages of
drug discovery
- A chapter on pharmacokinetics and pharmacodynamics that
discusses the issues faced during the final stages of the drug
development process
- The impact of International Conference on Harmonisation on the
use of single isomer drugs
- Chiral switches
- The concept of molecular chiral recognition and how it affects
the separation and behavior of stereochemically pure drugs
- A chapter on the legal perspectives of patent issues
surrounding chiral switches and the marketing of single enantiomer
switches
- This will be a one-stop shop for pharmaceutical scientists and
chemists working with chiral drug molecules
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