As pharmaceutical companies strive to develop safer medicines at a
lower cost, they must keep pace with the rapid growth of technology
and research methodologies. Defying the misconception of process
chemistry as mere scale-up work, Process Chemistry in the
Pharmaceutical Industry, Vol. 2: Challenges in an Ever Changing
Climate explores novel applications of synthetic, physical, and
analytical chemistry in drug discovery and development. It offers
an accurate depiction of the most up-to-date process research and
development methods applied to synthesis, clinical trials, and
commercializing drug candidates. The second installment in this
progressive series, this volumereviews the latest breakthroughs to
advance process chemistry, including asymmetric synthesis,
crystallization, morphology, enzymatic intervention, green
chemistry, macromolecules (monoclonal antibodies, biological
molecules, polymers), enantioselectivity, organometallic chemistry,
process analytical tools, chemical engineering controls, regulatory
compliance, and outsourcing/globalization. It explores new
approaches to synthetic processes, examines the latest safety
methods and experiment design, and suggests realistic solutions to
problems encountered in manufacturing and process development.
Significant topics include atom economy, ease of synthesis,
instrumentation, automization, quality control, cost
considerations, green practices, and future trends. Jointly edited
by the founder/president of Delphian Pharmaceuticals and the
director of Chemical R&D at Pfizer, this book brings together
contributions byreputed scientists, technologists, engineers, and
professors from leading academic institutions, such as the Imperial
College, UK, the University of Tokyo, ETH, Switzerland, the
International University at Bermen, Germany, and the University of
Connecticut, USA, and from principal pharmaceutical companies that
include Merck, Bristol Myers Squibb, Pfizer, Novartis, Eli Lilly,
Astrazeneca and DSM.
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