Skeletal muscle is a highly plastic tissue that constitutes
approximately thirty percent of total body mass and adapts rapidly
to changing functional demands. Skeletal muscle is not only the
generator of force production, but also plays a crucial role in
whole body metabolism and energy consumption. In this book, leading
experts in the area of exercise biochemistry and molecular biology
in skeletal muscle provide an up-to-date view of the molecular
basis of various adaptations of skeletal muscle, with emphasis on
new biological concepts (muscle stem cells, muscle steroidogenesis,
etc). This book deals with the recent intriguing role of heat shock
protein (HSP), AMPK and reactive oxygen species (ROS) for muscle
morphology, function and metabolism. Discussed also is the
molecular mechanism for protein metabolism and therapeutic
application for sarcopenia. The deeper understanding of the signal
transduction and modification in skeletal muscle will develop new
therapeutic strategies for preventing physical disability and
increased risk of morbidity/mortality due to the loss of muscle
mass.
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