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Radioimmunoassays for Insulin, C-Peptide and Proinsulin (Paperback, Softcover reprint of the original 1st ed. 1988)
Loot Price: R1,462
Discovery Miles 14 620
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Radioimmunoassays for Insulin, C-Peptide and Proinsulin (Paperback, Softcover reprint of the original 1st ed. 1988)
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THE DISCOVERY OF INSULIN, C-PEPTIDE AND PROINSULlN, SPECIES
DIFFERENCES Crude insulin was extracted and isolated from dog
pancreases removed 7-1 Degrees weeks after ligation of the
pancreatic duct for the first time in 1921 by Banting and Best. Its
lifesaving properties were subsequently documented in
pancreatectomized dogs in 1922. Only about six months elapsed from
its discovery until systematic collection of calf and ox pancreases
and, later, porcine pancreases was established and the blood
glucose lowering effect in diabetics using the crude extract from
these glands proven. It was not until 1960, however, that the
primary structure of all three species of insulin, lO7 human,
porcine and bovine, was elucidated . It then became evident that
the differences between bovine, porcine and human insulin amounted
to at mosl 3 amino acids. These apparently small differences have a
significant impact on the physico-chemical characteristics of the
three insulins which again affect, e.g., the rate of absorption of
insulin lO9 preparations from the subcutaneous tissue and their
immunogenicity, i.e.
General
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