That molecular neurobiology has become a dominant part of
neuroscience research can be credited to the discovery of inducible
gene expression in the brain and spinal cord. This volume deals
with genes, whose expression patterns in the vertebrate central
nervous system were the first to be revealed and then the most
extensively investigated over the last 15 years. Immediate early
genes (IEG) and their protein products, especially those acting as
regulators of transcription (inducible transcription factors, ITF)
have proven to be very valuable tools in functional neuroanatomy
and neurophysiology, as they are rapidly and transiently induced in
specific neurons in response to various modes of stimulation. Thus,
they have been used to map neuronal populations selectively
responsive to a variety of conditions, such as sensory and learning
experience, electrical stimulation of specific circuits, seizures,
and neurodegeneration.
This single volume, written by the most prominent authors in the
field, brings together for the first time information about the
most widely studied IEG/ITF in a whole variety of phenomena of
neuronal activation. It starts with a critical appraisal of the
technologies employed for the studies on gene, protein, and
transcription factor activity in the nervous system. Several
chapters present exhaustive examples of expression patterns of the
ITF in "vocal" avian brain, mammalian brain sensory regions, areas
involved in regulation of circadian rhythms, and the spinal cord.
The next parts cover functional and regular aspects of individual
IEG/ITF expression: c-fos in learning and memory, c-jun and others
in neuropathology and neuronal stress responses, Elk-1, egr family,
and CREB in neuronal plasticity and learning.
This volume will be useful as a major reference on this topic.
Furthermore, it attempts to unravel the seemingly overwhelming
complexity of the phenomena of gene expression in the central
nervous system.
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