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Books > Medicine > Clinical & internal medicine > Endocrinology > Diabetes
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Vasopressin - Disturbed Secretion and Its Effects (Paperback, Softcover reprint of the original 1st ed. 1989)
Loot Price: R1,617
Discovery Miles 16 170
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Vasopressin - Disturbed Secretion and Its Effects (Paperback, Softcover reprint of the original 1st ed. 1989)
Series: Developments in Nephrology, 25
Expected to ship within 10 - 15 working days
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The mechanisms by which animals regulate the volume and composition
of their body fluids has long had a particular fascination for
students of biology. As a consequence, the subject can lay claim to
an impressive record of ground breaking scientific achievements as
well as a provocative body of philosophical speculation concerning
the role of the system in the origin and evolution of life. Indeed,
the entire concept of homeostasis on which so much of o r current
biologic thinking is based, derives from Claude Bernard's
pioneering exploration of the forces that determine the composition
of this 'internal sea'. Other seminal achievements credited to this
area of inquiry include the first description of a genetically
transmitted human disease (familial neurogenic diabetes insipidus);
the first isolation sequencing and synthesis of a peptide hormone
(vasopressin and oxytocin); the first demonstration of peptide
hormone synthesis by way of a larger protein precursor; the first
description of resistance to the biologic actions of a hormone
(nephrogenic diabetes insipidus); and the conceptual realization of
the unique counter-current mechanism that permits concentration of
the urine. This record of far reaching and fundamental advances has
been distinguished by many fruitful inter actions between clinical
and basic science."
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