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Books > Medicine > Other branches of medicine > Pharmacology
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Cytokines and Pain (Hardcover, 1999 ed.)
Loot Price: R5,862
Discovery Miles 58 620
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Cytokines and Pain (Hardcover, 1999 ed.)
Series: Progress in Inflammation Research
Expected to ship within 10 - 15 working days
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Within the past few years, it has become recognized that the immune
system communicates to the brain. Substances released from
activated immune cells (cytokines) stimulate peripheral nerves,
thereby signaling the brain and spinal cord that
infection/inflammation has occurred. Additionally, peripheral
infection/inflammation leads to de novo synthesis and release of
cytokines within the brain and spinal cord. Thus, cytokines effect
neural activation both peripherally and centrally. Through this
communication pathway, cytokines such as interleukin-1,
interleukin-6 and tumor necrosis factor markedly alter brain
function, physiology and behavior. One important but
underrecognized aspect of this communication is the dramatic impact
that immune activation has on pain modulation. The purpose of this
book is to examine, for the first time, immune-to-brain
communication from the viewpoint of its effect on pain processing.
It is aimed both at the basic scientist and health care providers,
in order to clarify the major role that substances released by
immune cells play in pain modulation. This book contains chapters
contributed by all of the major laboratories focused on
understanding how cytokines modulate pain. These chapters provide a
unique vantage point from which to examine this question, as the
summarized work ranges from evolutionary approaches across diverse
species, to the basics of the immune response, to the effect of
cytokines on peripheral and central nervous system sites, to
therapeutic potential in humans.
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