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Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease (Hardcover, 2002 ed.)
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Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease (Hardcover, 2002 ed.)
Series: Advances in Experimental Medicine and Biology, 517
Expected to ship within 10 - 15 working days
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Parkinson's disease, a degenerative brain disorder, affects an
estimated 0.25-0.50% of the population. Symptoms result from
neuronal degeneration in the nigrostriatal dopaminergic pathway and
include tremor, rigidity and gradual slow- ness of spontaneous
movement. The cause of Parkinson's disease is only partially
understood; both environmental factors and a genetic predisposition
have been im- plicated in its etiopathogenesis. Neural
transplantation is being used experimentally for providing an
alternative biological source of dopamine both in animal studies
and in experimental clinical trials. This book is the result of 15
years of research on the transplantation of dopaminergic neurons in
the striatum of the weaver mouse, a neurological mutant
characterized by genetically-determined degeneration of midbrain
dopamine neurons. The weaver mouse constitutes the only available
laboratory model with a chronic progressive disease that mimics
Parkinsonism. The other two models currently used to investigate
dopaminergic mechanisms rely on the use of the neurotoxins-
hydroxydopamine and methylphenyltetrahydropyridine for the
selective removal of dopaminergic neurons from an otherwise healthy
organism. Structural and functional aspects of transplantation of
mesencephalic dopamin- ergic grafts into the striatum of weaver
mice are reviewed, including histochemical correlates of graft
survival and integration, numerical aspects of donor neuron
survival, ultrastructural findings on synaptogenesis, neurochemical
indices of dopam- ine uptake function and receptor binding, gene
expression of several structural and neurotransmitter-receptor
related molecules, the levels of striatal amino acid receptors, and
the behavioral effects of unilateral and bilateral neuronal
transplantations.
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