|
Books > Science & Mathematics > Biology, life sciences > Biochemistry > Biochemical immunology
|
Buy Now
Molecular Aspects of Innate and Adaptive Immunity (Hardcover)
Loot Price: R4,146
Discovery Miles 41 460
|
|
|
Molecular Aspects of Innate and Adaptive Immunity (Hardcover)
Expected to ship within 12 - 17 working days
|
The understanding, at the molecular level, of the interactions
between innate and adaptive arms of the immune system is currently
a hot topic, particularly to those interested in immunology -
especially susceptibility to infectious diseases. This book
provides a survey of topics, in the area of innate and adaptive
immunity, which have been researched within the MRC Immunochemistry
Unit, at Oxford University, over a period of forty years. The
topics include: " antibody structure - for which the first Director
of the Immunochemistry Unit, Professor RR Porter, was awarded a
Nobel prize in 1972 " the characterization of membrane proteins on
lymphoid cells - leading to the concept of these molecules
belonging to an immunoglobulin super family " the proteins of the
human serum complement system - one of the body's major defences
against microbial infection " the human cell -surface integrins and
the hyaluronan- binding proteins, which are involved in regulation
of inflammation at cell surfaces and within the extracellular
matrix " the family of collectin molecules - containing distinct
globular carbohydrate -binding domains linked to collagen-like
regions - which play important roles in innate immunity in the
lungs and bloodstream by immediate recognition and clearance of
microbial pathogens Each chapter in the book gives a brief
historical background to a topic and then provides a survey of
recent advances in the field and are written by internationally
recognised renowned experts. The theme running through the chapters
is that of protein structure-function relationships - including,
amongst others, descriptions of quaternary structures of large
oligomeric proteins, of Factor H and C1q binding to specific
ligands, and of the chemistry of the mechanism of catalysis of
covalent binding of activated C3 and C4 proteins to nucleophilic
groups on microbial surfaces. In several chapters excellent
descriptions are given with respect to how the immune system can be
recruited to combat microbial infection - via proteins of both the
innate and adaptive immune systems. The book also includes notable
chapters which are excellent examples of the importance of how the
isolation, characterisation, protein engineering and
crystallisation has resulted in a full understanding of complex
protein-protein interactions involved in the recognition and
triggering events of important sections of the immune system:
-Structure and Function of the C1 Complex - GUrard J. Arlaud
-Chemical Engineering of Therapeutic Antibodies - George T
Stevenson -Leukocyte surface proteins - purification and
characterisation - A. Neil Barclay -Cell Surface Integrins -
Suet-Mien Tan and S.K. Alex Law This book is aimed primarily at
established senior research scientists, postdoctoral research
scientists and PhD students who have an interest in proteins of the
immune system. However, the wide range of immunity system topics,
while staying broadly within innate/adaptive immunity will also
appeal to a wider audience.
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
|
You might also like..
|
Welcome to Loot.co.za!
Sign in / Register |Wishlists & Gift Vouchers |Help | Advanced search
