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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 7Role of Autophagy in Therapeutic Applications (Hardcover)
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 7Role of Autophagy in Therapeutic Applications (Hardcover)
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Understanding the importance and necessity of the role of autophagy
in health and disease is vital for the studies of cancer, aging,
neurodegeneration, immunology, and infectious diseases.
Comprehensive and up-to-date, this book offers a valuable guide to
these cellular processes whilst inciting researchers to explore
their potentially important connections. Volume 7 provides coverage
of the latest developments in autophagosome biogenesis and
regulation; the role of autophagy in protein quality control; and
the role of autophagy in apoptosis. Attention is given to autophagy
in the cardiovascular system, with particular insights into the
role of autophagy in atherosclerosis and the distinctive behavior
of autophagy in the sinoatrial node. Cutting-edge findings in the
relationships between autophagy and lifestyle are explored with the
regulation of macroautophagy in response to exercise, as well as
the promotion of carcinogenesis via autophagy in response to
cigarette smoking. Volume 7 highlights the importance of
understanding the role of autophagy in context, as the complexity
of autophagic function becomes increasingly clear. Autophagy may be
differentially regulated, and may perform distinctive cell-specific
functions even within a single tissue. The overall significance of
autophagy thus cannot be oversimplified, and must be explored with
granular detail of the specific role, function, and area of impact.
This book is an asset to newcomers as a concise overview of the
complex significance of autophagy, while serving as an excellent
reference for more experienced scientists and clinicians looking to
update their knowledge. Volumes in the Series Volume 1: Molecular
Mechanisms. Elucidates autophagy's association with numerous
biological processes, including cellular development and
differentiation, cancer, immunity, infectious diseases,
inflammation, maintenance of homeostasis, response to cellular
stress, and degenerative diseases such as Alzheimer's, Parkinson's,
Huntington's, amyotrophic lateral sclerosis, and prion diseases.
Volume 2: Role in General Diseases. Describes the various aspects
of the complex process of autophagy in a myriad of devastating
human diseases, expanding from a discussion of essential autophagic
functions into the role of autophagy in proteins, pathogens,
immunity, and general diseases. Volume 3: Role in Specific
Diseases. Explores the role of autophagy in specific diseases and
developments, including: Crohn's Disease, Gaucher Disease,
Huntington's Disease, HCV infection, osteoarthritis, and liver
injury, with a full section devoted to in-depth exploration of
autophagy in tumor development and cancer, as well as the
relationship between autophagy and apoptosis. Volume 4: Mitophagy.
Presents detailed information on the role of mitophagy, the
selective autophagy of mitochondria, in health and disease, by
delivering an in-depth treatment of the molecular mechanisms
involved in mitophagy initiation and execution, as well as the role
of mitophagy in Parkinson Disease, cardiac aging, and skeletal
muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively
describes the role of autophagy in human diseases, delivering
coverage of the antitumor and protumor roles of autophagy; the
therapeutic inhibition of autophagy in cancer; and the duality of
autophagy's effects in various cardiovascular, metabolic, and
neurodegenerative disorders. Volume 6: Regulation of Autophagy and
Selective Autophagy. Provides coverage of the mechanisms of
regulation of autophagy; intracellular pathogen use of the
autophagy mechanism; the role of autophagy in host immunity; and
selective autophagy. Volume 7: Role of Autophagy in Therapeutic
Applications. Provides coverage of the latest developments in
autophagosome biogenesis and regulation; the role of autophagy in
protein quality control; the role of autophagy in apoptosis;
autophagy in the cardiovascular system; and the relationships
between autophagy and lifestyle. Volume 8: Autophagy and Human
Diseases. Reviews recent advancements in the molecular mechanisms
underlying a large number of genetic and epigenetic diseases and
abnormalities, and introduces new, more effective therapeutic
strategies, in the development of targeted drugs and programmed
cell death, providing information that will aid on preventing
detrimental inflammation. Volume 9: Necrosis and Inflammation in
Human Diseases. Emphasizes the role of Autophagy in necrosis and
inflammation, explaining in detail the molecular mechanism(s)
underlying the formation of autophagosomes, including the
progression of Omegasomes to autophagosomes.
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