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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues
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Tumor Dormancy, Quiescence, and Senescence, Vol. 3 - Aging, Cancer, and Noncancer Pathologies (Hardcover, 2014 ed.)
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Tumor Dormancy, Quiescence, and Senescence, Vol. 3 - Aging, Cancer, and Noncancer Pathologies (Hardcover, 2014 ed.)
Series: Tumor Dormancy and Cellular Quiescence and Senescence, 3
Expected to ship within 12 - 17 working days
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This third volume in the series Tumor Dormancy, Quiescence, and
Senescence discusses the role of tumor dormancy and senescence in a
number of diseases, including breast cancer, ovarian cancer and
leukemia. The contents are organized under five subheadings:
General Applications, Role in Breast Cancer, Role in Ovarian
Cancer, Role in Leukemia and Role in Cardiovascular Disease. The
first section includes basic information on the definition of
dormancy, how cells become senescent and what they do, along with
an appraisal of the current state of research on dormancy. Section
Two explores dormancy in breast cancer, including the progression
of hormone-dependent mammary tumors after dormancy. Section Three
details the resistance of Type II ovarian tumors, in which the
resistant tumor cell population persists after chemotherapy in a
state of dormancy, with recurrent tumors arising upon
transformation of such dormant cells back to malignant growth. This
section explains how lineage, histological subtypes and grade
influence the differential response of ovarian cancer resistance to
platinum drugs. The fourth section explores leukemia, discussing
regulation of the promyelocytic leukemia protein and its role in
premature senescence. The final section explores the role of
senescence and autophagy in age-related cardiovascular diseases and
the observation that autophagy seems to retard cardiac senescence.
Like the two preceding volumes in the series, Volume 3 stands out
for its comprehensive approach, its roster of some 26 expert
contributors representing seven different countries and its
up-to-date review of leading-edge technology and methods.
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