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Molecular Components of Hepatitis B Virus (Paperback, Softcover reprint of the original 1st ed. 1985)
Loot Price: R4,438
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Molecular Components of Hepatitis B Virus (Paperback, Softcover reprint of the original 1st ed. 1985)
Series: Developments in Molecular Virology, 6
Expected to ship within 10 - 15 working days
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Since the discovery of Australia antigen and its association with
type B hepatitis, molecular characterization of the components
making up hepatitis B virus (RBV) have been pursued with worldwide
interest. Over the past two decades, such characterization has led
to the development of sensitive assays to screen and exclude
contaminated units from blood banks and has recently resulted in
the licensing of several RBV vaccines. That more than 200 million
people worldwide are chronically infected with RBV, and that they
are at a high risk for the development of chronic hepatitis and
hepatocellular carcinoma, still represent formidable problems in
our understanding of host-virus relationships on the molecular
level. In the absence of a suitable tissue culture system, and with
a very limited host range of infection, characterization of RBV on
the molecular level has made remarkable progress recently with the
advent of genome cloning, sequencing and expression of individual
virus genes by recombinant DNA technology. The presence of
hepatitis B-like viruses in an expanding number of animal hosts,
and the possibility of virus replication in cells other than
hepatocytes, provide great promise that future work will elucidate
the molecular mechanisms operative in the various outcomes of RBV
infection.
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