Provides expert, state-of-the-art insight into the current
progress of viral and non-viral gene therapyTranslational medicine
has opened the gateway to the era of personalized or precision
medicine. No longer a one-size-fits-all approach, the treatment of
cancer is now based on an understanding of underlying biologic
mechanisms and is increasingly being tailored to the molecular
specificity of a tumor.This book provides a comprehensive overview
of the pertinent molecular discoveries in the cancer field and
explains how these are being used for gene-based cancer therapies.
Designed as a volume in the Translational Oncology book series,
"Cancer Gene Therapy by Viral and Non-viral Vectors" deals with the
practice of gene-therapy, with reference to vectors for gene
expression and gene transfer, as well as viral therapy. It covers
the history and current and future applications of gene transfer in
cancer, and provides expert insight on the progress of viral and
non-viral gene therapy with regard to delivery system, vector
design, potential therapeutic genes, and principles and regulations
for cancer gene therapy. Presented in three parts, "Cancer Gene
Therapy by Viral and Non-viral Vectors" covers: Delivery Systems-
Translational Cancer Research: Gene Therapy by Viral and Non-viral
Vectors- Retroviruses for Cancer Therapy- DNA Plasmids for
Non-viral Gene Therapy of Cancer- Cancer Therapy with RNAi
delivered by Non-viral Membrane/Core Nanoparticles Targeted
Expression- Cancer Gene Therapy by Tissue-specific and
Cancer-targeting Promptors- MicroRNAs as Drugs and Drug Targets in
Cancer
Principles of Clinical Trials in Gene Therapy- Regulatory issues
for Manufacturers of Viral Vectors and Vector-transduced Cells for
Phase I/II Trials- US Regulations Governing Clinical Trials in Gene
Therapy- Remaining Obstacles to the Success of Cancer Gene
Therapy
Focusing on speeding the process in clinical cancer care by
bringing therapies as quickly as possible from bench to bedside,
"Cancer Gene Therapy by Viral and Non-viral Vectors" is an
absolutely vital book for physicians, clinicians, researchers, and
students involved in this area of medicine.
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