The goal in designing sustained release is reduce the frequency of
dosing or to increase the effectiveness of the drug by localization
at the site of action, reducing the dose required or providing the
uniform drug delivery. The use of controlled release (CR)
formulations offers many potential advantages such as, sustained
blood levels attenuation of adverse effects and improved patient's
compliance. It is important especially in the case of
antihypertensive agents, to maintain constant blood levels, as
other wise, dose dumping may cause hypo tension and
sub-therapeutical levels may cause hypertension. The objectives of
the present study was to Develop sustained release DTZ microsphere
by using different drug-polymer ratio, in vitro characterization of
DTZ, maintain more uniform drug plasma concentration, reduce dosing
frequency, avoidance of night time dosing, to estimate drug release
profile of the formulations, to choose the best formulation(s)
based on the above evaluations and finally to subject the most
satisfactory formulation(s) to accelerated stability studies.
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