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Viral Docking Protein Targeted Dapsone Delivery to Nerve Endings (Paperback)
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Viral Docking Protein Targeted Dapsone Delivery to Nerve Endings (Paperback)
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Leprosy is a neuropathic disease caused by the M.laprae, which
specially affect the nerves of the dermal tissue and multiply here.
Conventional treatment is based on antibiotics and essentially
Dapsone, which is the core drug for all leprosy treatment. Leprosy
requires high doses of Dapsone for very long period of time, which
in turn, is responsible for the side effect. Such prolonged
therapy, with untoward side effects, is a major draw back. Thus it
is desirable to make a dosage form, which could avoid most of the
adverse effect of Dapsone, and preparing the liposome of the drug
can do it. But only drug bearing liposomes don't have the targeting
ability. To make liposomes targetable, liposomes are coated with
the viral or bacterial docking proteins of bacterial or synthetic
origin, which are simply the bacterial or viral proteins that make
the attachment of bacteria/virus to the specific cell receptors for
the fusion with cell membrane and causing invasion into the cell.
In the case of leprosy a liposome based system could be developed
and targeted to nerve endings where the bacterial load is high
where they proliferate in tissue specific manner.
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