Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative
disorder characterized by the selective death of subsets of
motorneuorn (MN) populations in the brainstem and spinal cord with
signature hallmarks of mitochondrial Ca2+ overload, homeostasis
dysregulation, excitotoxicity, impaired axonal transport, muscle
weakness and paralysis. Although disruptions of cytosolic and
mitochondrial Ca2+ (in particular low ( Ca2]]i) buffering and a
strong interaction between metabolic mechanisms and Ca2]]i) have
been associated with selective motoneuron degeneration, the
underlying mechanisms are not well understood. The present evidence
supports a hypothesis that mitochondria are a primary target of
SOD1-mediated toxicity in ALS, and intracellular alterations of
cytosolic and mitochondria-ER microdomain calcium accumulation
might aggravate the course of this neurodegenerative disease. This
book aims to provide an overview of the known players and their
interactions, their role in the selective MN loss, recent advances
in this field and a detailed discussion about what has been learned
about Ca2+ homeostasis and the role of mitochondria in MNs in
pathophysiological conditions.
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
Germany |
Release date: |
March 2012 |
First published: |
March 2012 |
Authors: |
Manoj Kumar Jaiswal
|
Dimensions: |
229 x 152 x 10mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
180 |
ISBN-13: |
978-3-8484-4969-9 |
Categories: |
Books >
Medicine >
General issues >
General
|
LSN: |
3-8484-4969-2 |
Barcode: |
9783848449699 |
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