Cancer is a major health problem worldwide and is one of the most
prominent causes of morbidity and mortality in children and adults
causing about 9 million deaths annually. The success of novel
cancer therapies depends on the identification of functional
targets that play an essential role in tumor growth and metastasis,
survival and evasion from immunosurveillance. Costimulation through
CD80 or through CD28-bearing T cells, regresses the growth in B
cell lymphomas retard the proliferation and induce apoptosis. On
the other hand Tuberculosis(MTB) a major infectious disease is
becoming global emergency due to BCG failure and multidrug
resistance and hence needs urgent attention from scientific
community to develop alternative strategies to defeat the problems
linked to the reemergence of TB. Macrophages activated through
anti-B7-1 and anti-B7-2 mAbs showed enhanced microbicidal function
and reduced the survival of MTB. Therefore this novel strategy can
be effectively exploited to develop immunotherapy either using
humanized antibodies against CD80 or CD86 or CD28 fusogenic
proteins for the treatment of cancer especially relapse and
refractory lymphomas and intracellular pathogens.
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