Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Targeted Therapies in Cancer (Hardcover)
Loot Price: R3,293
Discovery Miles 32 930
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Targeted Therapies in Cancer (Hardcover)
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Since the year 2000, exciting developments in cancer therapy have
occurred. For decades in the 20th century, the hallmark of medical
treatment for cancer had been cytotoxic chemotherapy, with drugs
targeting rapidly dividing cells, including cancer cells but also
certain normal tissues. As a result, many patients experienced the
"classic" toxicities of alopecia, gastrointestinal symptoms and/or
myelosuppression. In the last years, however, clinical research has
been strongly occupied with the identification of mutations and
aberrations concerning molecular pathways in cancer and their
alterations, which has enabled the emergence of a "targeted"
(somewhat personalized) medicine approach to treatment. Today,
although traditional cytotoxic chemotherapy remains the treatment
of choice for many malignancies, notably as first-line agents,
targeted therapies are a possible choice for many types of cancer,
including breast, prostate, CRC, lung, kidney cancers, as well as
lymphoma, leukaemia, and myeloma. Over 60 of these targeted
therapies recently approved by the United States Food and Drug
Administration (FDA) are detailed in the book, and their intended
use in one or more cancer types are shown.
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