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Books > Professional & Technical > Veterinary science
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Environmental Metal Pollutants, Reactive Oxygen Intermediaries and Genotoxicity - Molecular Approaches to Determine Mechanisms of Toxicity (Paperback, Softcover reprint of the original 1st ed. 1999)
Loot Price: R2,738
Discovery Miles 27 380
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Environmental Metal Pollutants, Reactive Oxygen Intermediaries and Genotoxicity - Molecular Approaches to Determine Mechanisms of Toxicity (Paperback, Softcover reprint of the original 1st ed. 1999)
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Humans are exposed daily to low concentrations of metals that are
released into the environment by both natural and industrial
processes. Environmental Metal Pollutants, Reactive Oxygen
Intermediaries and Genotoxicity: Molecular Approaches to Determine
Mechanisms of Toxicity examines concerns about the acute and/or
chronic exposure of humans to concentrations of these metals that
are below the threshold levels established by various federal
regulatory agencies. Some of these metals are accumulated in
various tissues and over time this may result in the accumulation
of a significant body burden. This could increase the risk of
developing a variety of diseases later in life, at a time when
thresholds for such effects may already be reduced by the processes
of aging. Such possibilities could only further compromise the
quality of life in the elderly population and could contribute to
the rising cost of health care in this country. Studies that have
been conducted to determine the possible risks associated with
exposure to relatively non-toxic concentrations of environmental
metals have been hampered by a lack of appropriate models and a
lack of funding. It has also been difficult for researchers to
demonstrate a correlation between the exposure of humans or animals
to low concentrations of environmental pollutants and disease. This
book examines recent technological advances in the areas of
molecular biology, biochemistry, and computer-enhanced image
analyses that provide researchers with the tools to begin
elucidating the genotoxic effects of environmental metal pollutants
and the mechanisms by which these metals cause DNA damage.
Environmental Metal Pollutants, Reactive Oxygen Intermediaries and
Genotoxicity: Molecular Approaches to Determine Mechanisms of
Toxicity presents data that demonstrate that certain environmental
metal pollutants are genotoxic. The authors describe the role of
reactive oxygen intermediates in causing the DNA damage induced by
environmental metal pollutants and discuss their possible role in
human disease.
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