Books > Medicine > Other branches of medicine > Pharmacology
|
Buy Now
Antimicrobial Peptides (Hardcover)
Loot Price: R4,371
Discovery Miles 43 710
You Save: R238
(5%)
|
|
Antimicrobial Peptides (Hardcover)
Expected to ship within 12 - 17 working days
|
Countless studies have exhibited the fact that despite growing
problems with resistance to antimicrobial agents amongst vital
bacterial pathogens, the quantity of new antibiotics have been
brought to the market has exposed a quick failure over the past
several decades. Moreover, the requirement for alternative
therapeutic possibilities as the antimicrobial peptides (AMPs) has
become urgent. A complete understanding of the action of AMPs is of
highest significance at a time when the first AMP is about to reach
the market, both in terms of understanding the penalty of use and
the design of improved drugs. The book begins with a short
introduction that provides an overview of history, structure,
classification and mechanism of action of the AMPs. In this book,
AMPs are categorized by their target and mode of action. For
natural AMPs, we will emphasis on those from eukaryotes. Part 1
focuses on antivirial AMPs that neutralize viruses by integrating
into either the viral envelope or the host cell membrane. It
appears to be difficult to predict antiviral activity based on
secondary structures of peptides, for this reason are discussed
AMPs with different structures as Mellitin (a-helix), Mastoparan
(a-helix), Defensin (b-sheet) and Protegrin (b-sheet). Part 2 shows
selected examples of natural antibacterial peptides. Antibacterial
AMPs are the most studied AMPs and most of them are cationic, which
target bacterial cell membranes and cause breakdown of the lipid
bilayer structure. As consequence, Part 3 covers AMPs with an
antifungal activity which has a unique structure-activity
relationship because their sequences tend to be relatively rich in
polar and neutral amino acids. Their mode of action was first
described as involving either fungal cell lysis or interference
with fungal cell wall synthesis. Antiparasitic peptides are a
smaller group compared to other three AMP classes and they are the
subject of the overview of Part 4. Finally, the last Part 5 focuses
on novel strategies for designing of new synthetic AMPs.
Clarification of the activity pathways as well as search of
correlations between activity and features like hydrophobicity,
hydrophilicity, charge, etc., will allow the developing of new
artificial AMPs with augmented activity by means of appropriate
amino acid replacements.
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
|
|
Email address subscribed successfully.
A activation email has been sent to you.
Please click the link in that email to activate your subscription.